What is thyroglobulin and its function?

Thyroglobulin (Tg) acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle.

What is thyroglobulin made of?

Thyroglobulin is an essential substrate for organification and is the major protein component of the colloid in the thyroid follicular lumen. It is an iodinated glycoprotein with a molecular weight approximating 650,000 daltons. It consists of two monomeric chains, each with 67 tyrosine residues.

How does thyroglobulin become thyroid hormone?

Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct …

Where is thyroglobulin located?

the thyroid gland
Thyroglobulin is the protein precursor of thyroid hormones, which are essential for growth, development and control of metabolism in vertebrates1,2. Hormone synthesis from thyroglobulin (TG) occurs in the thyroid gland via the iodination and coupling of pairs of tyrosines and is completed by TG proteolysis3.

What is thyroglobulin in biology?

Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic reticulum (ER), where it acquires N-linked glycosylation and conformational maturation (including formation of many disulfide bonds), leading to homodimerization.

Is thyroglobulin the same as globulin?

Thyroglobulin is the protein produced in the thyroid follicles and takes part in the thyroxine formation. Thyroxine binding globulins are the protein that binds with thyroxine.

Is thyroglobulin a prohormone?

product of thyroid gland … colloid that contains the prohormone thyroglobulin. The follicular cells contain the enzymes needed to synthesize thyroglobulin, as well as the enzymes needed to release thyroid hormone from thyroglobulin.

What is the medical term for thyroglobulin?

(THY-roh-GLAH-byoo-lin) The form that thyroid hormone takes when stored in the cells of the thyroid.

Is thyroglobulin present in blood?

Thyroglobulin (Tg) is a very abundant protein found only in thyroid tissue. Even a trace of thyroglobulin in the blood indicates that normal or abnormal thyroid tissue is present.

What is a thyroglobulin antibody?

Antithyroglobulin antibody is a test to measure antibodies to a protein called thyroglobulin. This protein is found in thyroid cells. Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand.

Is thyroglobulin made from tyrosine?

Thyroglobulin contains ~70 tyrosine residues; however, only a few tyrosine residues are capable of synthesizing thyroid hormones. T4 is primarily formed at a conserved site near the amino terminus (red), and T3 is mainly synthesized at conserved sites in the carboxy terminus (blue).

What is difference between thyroglobulin and TSH?

More TSH helps the thyroid to make more thyroid hormone and also thyroglobulin. If your TSH is too high, it may cause any thyroid cancer cells you may have to grow. What are Thyroglobulin Antibodies (TgAb)? Thyroglobulin antibodies (TgAb) are proteins that can be measured in your blood.