What is the value of alpha-lipoic acid?

Alpha-lipoic acid is an organic compound with antioxidant properties. It’s made in small amounts by your body but also found in foods and as a supplement. It may benefit diabetes, skin aging, memory, heart health, and weight loss. Dosages of 300–600 mg seem effective and safe without serious side effects.

Is alpha-lipoic acid an acid?

Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. It is used to break down carbohydrates and to make energy. Alpha-lipoic acid can be eaten in foods, such as red meat, carrots, beets, spinach, broccoli, and potatoes. It is also available in supplements.

Is lipoic acid soluble in water?

Water
Ethanol
Alpha Lipoic Acid/Soluble in

Is lipoic acid a reducing agent?

Lipoic acid in a cell seems primarily to induce the oxidative stress response rather than directly scavenge free radicals. This effect is specific for RLA. Despite the strongly reducing milieu, LA has been detected intracellularly in both oxidized and reduced forms.

Which vitamin is lipoic acid?

Lipoic acid is another B-complex vitamin, whose only known function is to participate in the oxidative decarboxylations of α-ketoacids, principally conversion of pyruvate to acetyl-CoA, and α-ketoglutarate to succi-nyl-CoA, two similar dehydrogenase complexes of the TCA cycle.

What is the PH of alpha-lipoic acid?

Alpha lipoic acid (ALA) derives its name because of its higher degree of solubility in lipid and its acidic nature (pKa = 4.7). It helps in a number of in vivo reactions, like in a transfer of hydrogen and acyl groups in oxidative decarboxylation of α-keto acids. ALA acts as the chelator for metal in lead toxicity [1].

How do you dissolve lipoic acid?

DL-α-lipoic acid is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, DL-α-lipoic acid should first be dissolved in ethanol and then diluted with the aqueous buffer of choice.

Is lipoic acid a fatty acid?

α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review. Nutr Neurosci. 2019 May;22(5):306-316.

What oxidized lipoic acid?

Lipoic acid is an essential cofactor for the oxidative decarboxylations of α-keto acids where, linked to the ε-amino group of a lysine residue of the enzyme dihydrolipoyl transacetylase, it is one of several prosthetic groups in the multi-enzyme, lactate dehydrogenase complex.

Which is better R Ala or S ALA?

R-ALA is the form found naturally in the body and S-ALA is a synthetic byproduct created during the production of ALA. When selecting a supplement, be sure to look for 100% R-ALA; otherwise you’re probably getting a mixture. Studies suggest the naturally occurring form is more bioavailable.

Which form of lipoic acid is best?

A liquid formulation of R-lipoic acid was found to be better absorbed and more stable in the plasma, suggesting that it might be more efficacious than the solid form in the management of a condition like diabetic neuropathy (9, 10). There may also be differences in bioavailability of the two isomers of lipoic acid.