What is the treatment of choice in Pneumocystis carinii?

The drug of choice for treatment and prophylaxis is trimethoprim-sulfamethoxazole, but alternatives are often needed because of adverse effects or, less commonly, treatment failure. Adjunctive corticosteroid therapy improves survival in moderate to severe cases.

Is Pneumocystis carinii primary or secondary?

Pneumocystis carinii is an important opportun- istic pathogen in patients with poor T lym- phocyte function as a result of either primary or secondary immunodeficiency.

Which drugs are most effective at treating Pneumocystis carinii infections?

Trimethoprim-sulfamethoxazole. TMP-SMX is the agent of choice for the treatment of Pneumocystis pneumonia and extrapulmonary disease in all hosts who tolerate this combination agent (11, 26, 48, 59).

What is primary and secondary prophylaxis of opportunistic infections?

Definition. Opportunistic infections are intercurrent infections that occur in people infected with HIV. Prophylaxis aims to avoid either the first occurrence of these infections (primary prophylaxis) or their recurrence (secondary prophylaxis, maintenance treatment).

What is Pneumocystis carinii infection?

Pneumocystis jiroveci pneumonia is a fungal infection of the lungs. The disease used to be called Pneumocystis carini or PCP pneumonia. AIDS (acquired immune deficiency syndrome) is caused by HIV (human immunodeficiency virus), and is a syndrome that leaves the body vulnerable to a host of life-threatening illnesses.

Which one of the following medications provides sufficient prophylaxis for both Pneumocystis pneumonia and toxoplasma encephalitis?

Recommended Regimens for Primary Prophylaxis [17] Note that all recommended regimens for Toxoplasma encephalitis prophylaxis are also effective for Pneumocystis pneumonia prophylaxis. Preferred Therapy: Trimethoprim-sulfamethoxazole is the preferred agent for Toxoplasma encephalitis prophylaxis in individuals with HIV.

When do you start PJP prophylaxis?

For recipients of solid organ transplant, guidelines recommend primary prophylaxis for a minimum of 6 months after transplant. Some patients, such as lung and small bowel transplant recipients or those with a history of PCP infection or chronic cytomegalovirus infection, have indications for lifelong prophylaxis.

What is primary infection?

Definition of primary infection : the initial infection of a host by a pathogen that has completed a resting or dormant period.

What drug treats Pneumocystis jiroveci?

Answer. While officially classified as a fungal pneumonia, P jiroveci pneumonia (PJP) does not respond to antifungal treatment. The treatment of choice is TMP-SMX, with second-line agents including pentamidine, dapsone (often in combination with pyrimethamine), or atovaquone.