What is the role of c-Myc in cancer?

The c-Myc gene serves as a “master regulator” of cellular metabolism and proliferation. Since it is activated by a large number of oncogenic pathways and, in turn, stimulates many of the metabolic changes that result in malignant transformation, it is truly “both the chicken and the egg”.

What is the difference between c-Myc and MYC?

Myc and c-myc are the same thing, the normal cellular (hence the c) version of this protein, which can be oncogenic when mutated. The myc tag is a 10-residue sequence derived from c-myc, which is a much larger protein.

What does c-Myc regulate?

C-Myc. C-Myc protein is a member of a family of proteins that regulate cell proliferation and apoptosis. The ability of c-myc to regulate apoptotic cell death results from the coordinated activation of c-Myc and several protein partners (such as Max) that facilitate DNA binding and activate transcription.

What does C-myc positive mean?

c-MYC expression is considered positive when >40% of the lymphoma cells are stained [49]. c-MYC expression detected by immunohistochemistry (IHC) does not equate to c-MYC rearrangement. However, there is a correlation between c-MYC expression by IHC and c-MYC gene abnormalities in aggressive B-cell lymphomas [53].

How does MYC cause apoptosis?

c-MYC represses some of the survival pathways associated with death receptor and DISC activation, and this can promote apoptosis. Death receptor signaling can activate the nuclear factor-κB (NF-κB) transcription factor, which suppresses receptor-induced apoptosis.

Where is C-MYC expressed?

chromosome 8
In the human genome, C-myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes).

Is myc an oncogene or tumor suppressor?

Although the Myc gene was originally identified as an oncogene, it is involved in various cellular processes, including cell growth, proliferation, loss of differentiation, and apoptosis (Adhikary and Eilers, 2005; Pelengaris et al., 2002; Thompson, 1998).

Is Myc an oncogene or tumor suppressor?

Why is Myc hard Targeting?

Yet, drug development aimed at directly targeting Myc has proved challenging. First, as a transcription factor, Myc lacks a specific active site for small molecules, making it difficult to functionally inhibit its activities using strategies similar to those used for kinases.

How does Myc cause apoptosis?

What DNA structure does C-Myc bind in DNA?

The c-Myc protein is a potential activator of transcription, with the ability to bind in a heterodimer form with Max to DNA sequences containing the core hexanucleotide sequence CAC(G/A)TG.