What is the purpose of hematopoietic stem cell transplantation?

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective.

What it means autologous transplantation?

Listen to pronunciation. (aw-TAH-luh-gus TRANZ-plant) A procedure in which a patient’s healthy stem cells (blood-forming cells) are collected from the blood or bone marrow before treatment, stored, and then given back to the patient after treatment.

What is the hematopoietic stem cell theory?

(hee-MA-toh-poy-EH-tik stem sel) An immature cell that can develop into all types of blood cells, including white blood cells, red blood cells, and platelets. Hematopoietic stem cells are found in the peripheral blood and the bone marrow. Also called blood stem cell.

What is HSC in immunology?

Hematopoietic stem cells (HSCs) can self-renew and give rise to all the cells of the blood and the immune system. As they differentiate, HSCs progressively lose their self-renewal capacity and generate lineage-restricted multipotential progenitor cells that in turn give rise to mature cells.

What is the role of hematopoietic stem cells?

Hematopoietic stem cells (HSCs) are responsible for the production of mature blood cells in bone marrow; peripheral pancytopenia is a common clinical presentation resulting from several different conditions, including hematological or extra-hematological diseases (mostly cancers) affecting the marrow function, as well …

What is autologous hematopoietic stem cell transplantation?

Autologous hematopoietic stem cell transplantation (aHSCT) is a type of bone marrow transplantation that attempts to reset the immune system, which is responsible for damaging the brain and spinal cord in multiple sclerosis.

How do HSC differentiate?

Model of the hematopoietic hierarchy Throughout differentiation, a HSC first loses self-renewal capacity, then loses lineage potential step-by-step as it commits to become a mature functional cell of a certain lineage. The cell surface phenotype of each population is shown for the mouse and human systems.