What is the pathophysiology of lupus nephritis?

Lupus nephritis occurs when lupus autoantibodies affect structures in your kidneys that filter out waste. This causes kidney inflammation and may lead to blood in the urine, protein in the urine, high blood pressure, impaired kidney function or even kidney failure.

What is diffuse lupus?

Class IV is defined as diffuse lupus nephritis involving 50% or more of glomeruli in the biopsy. In the affected glomeruli, the lesions as described below may be segmental, defined as sparing at least half of the glomerular tuft, or global, defined as involving more than half of the glomerular tuft.

What is the main mechanism of pathophysiology of SLE?

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE.

What is most common pathogenesis of lupus glomerulonephritis?

Results: The pathogenesis of lupus nephritis is based (1) on the mechanisms that lead to loss of tolerance against nuclear autoantigens, i.e. systemic lupus, and then (2) on the mechanisms of immune complex-induced intrarenal inflammation.

What is the difference between lupus and lupus nephritis?

Lupus is basically an autoimmune disease in which your own immune system starts to cause inflammation and damage to pretty much any organ system in your body. The difference between lupus—which can be limited to the skin, joints, or other organs—and lupus nephritis is that the kidney is involved in lupus nephritis.

What’s the difference between lupus and lupus nephritis?

With lupus, the body’s immune system targets its own body tissues. Lupus nephritis happens when lupus involves the kidneys. Up to 60% of lupus patients will develop lupus nephritis.

What are the four stages of lupus?

When people talk about lupus, they may be referring to the most common form—systemic lupus erythematosus (SLE). However, there are actually four kinds. Click or scroll to read more about each of them: SLE, cutaneous lupus, drug-induced lupus, and neonatal lupus.

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