What is the mechanism of action of regorafenib?

CF The mechanism of action of regorafenib (Stivarga, Bayer) is very similar to that of sorafenib (Nexavar, Bayer). They are both oral multikinase inhibitors. Essentially, they block tyrosine kinases that are very active in angiogenesis, cancer development and growth, and maintenance of the tumor microenvironment.

How effective is regorafenib?

Regarding the efficacy of regorafenib, ORR and DCR were 3.1% and 54.2%, respectively, consistent with that the phase III CONCUR clinical trial of regorafenib for mCRC (ORR 4% and DCR 51% in the regorafenib arm).

Is regorafenib a TKI?

Abstract. Regorafenib is a novel oral multitargeted tyrosine kinase inhibitor having both antitumor and anti-angiogenic activities.

What is regorafenib used for?

Regorafenib is used to treat metastatic cancer (cancer that has spread) of the colon and rectum. It is used in patients who have already been treated with other cancer medicines that did not work well. Regorafenib prevents the growth of tumors.

Is regorafenib an immunotherapy?

Regorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

How much does regorafenib cost?

Including adverse events, the price of regorafenib equaled $39,391 for the total treatment duration.

How long can you take stivarga?

How long will I be taking STIVARGA? The recommended dose of STIVARGA is 160 mg (four 40-mg tablets) every day for 3 weeks, followed by a 1-week break. This is 1 cycle of treatment. Your doctor may stop your treatment or change the dose.

Is regorafenib a BRAF inhibitor?

Regorafenib is a small molecular inhibitor of multiple kinases including BRAF, VEGFR 1/2/3, TIE2, PDGFR, FGFR, RAF-1, KIT and RET …

What type of drug is regorafenib?

Regorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply.

Is regorafenib cytotoxic?

With this in mind, we used the Chou-Talalay median effects analysis to demonstrate that the combination of regorafenib with a PKD inhibitor resulted in a significant synergistic cytotoxic effect in CRC cells that expressed different genetic mutation profiles.

What are the side effects of regorafenib?

Common side effects of Stivarga include:

  • weakness/fatigue,
  • loss of appetite and decreased food intake,
  • hand-foot skin reaction (HFSR),
  • diarrhea,
  • stomach pain,
  • weight loss,
  • infection,
  • high blood pressure (hypertension),