What is the meaning of diethylstilbestrol?

(dy-EH-thul-stil-BES-trol) A synthetic form of the hormone estrogen that was prescribed to pregnant women between about 1940 and 1971 because it was thought to prevent miscarriages. Diethylstilbestrol may increase the risk of uterine, ovarian, or breast cancer in women who took it.

What are the side effects of diethylstilbestrol?

Side-effects of the treatment include feeling sick (nausea), swollen feet and ankles and an increased risk of blood clots. Impotence and breast enlargement can occur in men.

What are the post DES problems of daughters?

DES daughters have a higher risk of developing certain cervical and vaginal cancers and pre-cancerous conditions. You should have a special DES check-up every year, along with annual clinical breast examination and mammography, once you have reached 40 years of age.

How was DES administered?

DES was given in pills, injections, and vaginal suppositories (sometimes called pessaries).

What is DES in medical terms?

What is DES? Diethylstilbestrol (DES) is a synthetic form of the female hormone estrogen. It was prescribed to pregnant women between 1940 and 1971 to prevent miscarriage, premature labor, and related complications of pregnancy (1).

What is diethylstilbestrol used for today?

Today, diethylstilbestrol (DES) is used in men to treat prostate cancer and for palliative care to manage symptoms caused by prostate cancer treatment. It is also used in veterinary medicine to treat urinary incontinence in female dogs.

Can humans take Stilbestrol?

CAUTIONS: Some estrogens have been associated with bone marrow suppression and an increased risk of mammary tumors. WARNINGS: FEDERAL LAW PROHIBITS THE ADMINISTRATION OF THIS PREPARATION TO ANIMALS THAT PRODUCE FOOD OR THAT ARE INTENDED FOR CONSUMPTION AS FOOD. Not for Human use.

Can DES affect grandchildren?

The endocrine disrupting chemical diethylstilbestrol (DES), which has been banned in the U.S. since 1971, may be linked to increased odds of attention-deficit/hyperactivity disorder (ADHD) in grandchildren of the women who used it, a large-scale cohort analysis suggests.

Is DES the same as thalidomide?

These drugs were differentially marketed worldwide. As dis- cussed later, DES was primarily an American tragedy, thalidomide was a northern European and United Kingdom tragedy, and Bendectin/ Debendox was marketed to American, European, and United Kingdom populations.

How does diethylstilbestrol affect the endocrine system?

“In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: An epigenetic mechanism linking endocrine disruptors to breast cancer.” Hormones and Cancer 1 (2010): 146–55.

Is diethylstilbestrol banned?

Diethylstilbestrol (DES) DES is a nonsteroidal estrogen that was prescribed for decades to pregnant women in order to prevent miscarriage and premature delivery. It was banned in the United States in 1972 and in France in 1977.

Can DES cause birth defects?

In addition to its carcinogenic properties, DES is a known teratogen, an agent capable of causing malformations in daughters and sons who were exposed in utero.