What is the difference between spherocytosis and Elliptocytosis?

Hereditary spherocytosis is characterized by hemolysis of spheroidal RBCs and anemia. Hereditary elliptocytosis (ovalocytosis) is a rare autosomal dominant disorder in which RBCs are oval or elliptical.

What does spherocytosis mean?

Collapse Section. Hereditary spherocytosis is a condition that affects red blood cells. People with this condition typically experience a shortage of red blood cells (anemia ), yellowing of the eyes and skin (jaundice), and an enlarged spleen (splenomegaly).

What does it mean if you have elliptocytes?

Hereditary elliptocytosis (HE) refers to a group of inherited blood conditions where the red blood cells are abnormally shaped. Symptoms vary from very mild to severe and can include fatigue, shortness of breath, gallstones, and yellowing of the skin and eyes (jaundice).

What organelle is associated with hereditary elliptocytosis?

Hereditary elliptocytosis (HE) is a group of disorders of the red blood cell (RBC) membrane that are characterized by elliptical-shaped erythrocytes (elliptocytes; see the image below) and shortened RBC survival.

What is hereditary Elliptocytosis?

Hereditary elliptocytosis (HE), also called hereditary ovalocytosis, is a heterogeneous group of inherited red blood cell (RBC) disorders characterized by the presence of elongated, oval, or elliptically shaped RBCs on the peripheral blood smear.

What are the symptoms of spherocytosis?

Symptoms

  • fatigue.
  • shortness of breath.
  • irritability.
  • dizziness or lightheadedness.
  • increased heart rate.
  • headache.
  • heart palpitations.
  • jaundice.

Why do elliptocytes form?

Cell Formation: Formation occurs due to erythrocyte membrane protein defects resulting in an increase in mechanical weakness and membrane fragility. Hereditary elliptocytosis occurs due to defects in the horizontal protein linkages between the membrane and cytoskeleton.

Is Spherocytosis hereditary?

Hereditary spherocytosis (HS) is an inherited disease that affects the red blood cells. Characteristic symptoms of HS are the destruction of red blood cells in the spleen and their removal from the blood stream (hemolytic anemia), a yellow tone to the skin (jaundice), and an enlarged spleen (splenomegaly).

What is the difference between ovalocytes and elliptocytes?

Elliptocytes: Red blood cells are cigar or pencil shaped with parallel sides and an area of pallor. Ovalocytes: Are red blood cells that are oval or egg shaped.