What is the difference between glargine and degludec?

What is the difference between glargine and degludec?

Conclusions: Compared with glargine, degludec is associated with equivalent HbA1c control and significantly lower nocturnal hypoglycemia rates. In T1DMB/B and T2DMinsulin-naïve, degludec is also associated with significantly greater reductions in FPG and lower total doses of insulin versus glargine.

What is degludec used to treat?

Insulin degludec is used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).

How do you start a degludec?

1. Start insulin degludec/insulin aspart 70/30 at the same unit dose and injection schedule as the premix or self-mix insulin.
2. In patients also using short- or rapid-acting insulin at mealtimes, continue the short- or rapid-acting insulin at the same dose for meals NOT covered by degludec/insulin aspart 70/30.

Is tresiba and degludec the same?

Tresiba is a biologic drug that contains the active drug insulin degludec. It’s available only as a brand-name medication. Tresiba doesn’t come in a biosimilar form.

What type of insulin is degludec?

TRESIBA (insulin degludec injection) is a long-acting basal human insulin analog for subcutaneous injection.

What is the meaning of degludec?

Insulin degludec (INN/USAN) is an ultralong-acting basal insulin analogue that was developed by Novo Nordisk under the brand name Tresiba. It is administered via subcutaneous injection once daily to help control the blood sugar level of those with diabetes.

What is the half life of degludec?

The insulin degludec half-life was 40.76 h. Conclusion: Although the reported half-life of insulin degludec in the body is ~25 h when administered in standard doses (0.4-0.8 units/kg), no study has investigated its half-life after overdose.

Is degludec long-acting?

Insulin degludec is a new generation, ultra-long-acting basal insulin that forms soluble multihexamers at the injection site that slowly release insulin degludec monomers into the circulation giving a prolonged duration of action.

How do you adjust a degludec?

Suggested starting dose is 10 units once daily at bedtime. Suggested titration is 1 unit per day until targets is reached. (Degludec should be titrated by 2 units every 3 to 4 days or 4 units once a week).

What insulin can be mixed with degludec?

The 2 recently FDA-approved insulins—insulin degludec, a novel formulation of long-acting insulin, and the combination of insulin degludec plus insulin aspart, a rapid-acting insulin—have demonstrated efficacy and acceptable safety comparable to that of currently available basal insulin drugs for the treatment of …

How long-acting is degludec?

PK/PD studies show that insulin degludec has a very long duration of action, with a half-life exceeding 25 h. Once-daily dosing produces a steady-state profile characterized by a near-constant effect, which varies little from injection to injection in a given patient.