What is Tetracosactide used for?

Tetracosactide is a diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency. Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone.

How do you read Synacthen results?

Result Interpretation A cortisol of >420nmol/L at 30 minutes post Synacthen indicates an adequate adrenal response. Failure to meet the above criteria indicates probable Addison’s disease or very marked adrenal atrophy secondary to prolonged absence of ACTH stimulation.

What happens in a short Synacthen test?

A synacthen test uses a special chemical (synacthen) to test how well the adrenal glands make cortisol. It involves stimulating the adrenal glands and then checking to see if they respond. You need to fast from midnight but you can take painkillers with water.

Is Tetracosactide a corticosteroid?

Description: Tetracosactide is a synthetic polypeptide that stimulates the adrenal cortex to secrete adrenal steroids (including hydrocortisone, cortisone), androgenic substances, and to a lesser extent, aldosterone. Synonyms: tetracosactrin, cosyntropin.

How does ACTH Stim test work?

Your blood is drawn. You then receive a shot (injection) of ACTH, usually into the muscle in your shoulder. The ACTH may be a man-made (synthetic) form. After either 30 minutes or 60 minutes, or both, depending on how much ACTH you receive, your blood is drawn again.

What is a normal cortisol level?

Cortisol levels are often measured to evaluate the pituitary and adrenal function. Normal Values: Normal values at 8 a.m.are 6 to 23 mcg/dl. Normal value ranges may vary slightly among different laboratories.

When is a synacthen test performed?

Diagnosis and characterisation of 21-hydroxylase deficiency and other causes of adrenal hyperplasia can use a Short Synacthen Test. SST should be done in the follicular phase because 17OH progesterone is increased after ovulation. On the samples taken for cortisol, 17- hydroxy progesterone (17OHP) should be requested.

When should synacthen test be done?

What is ACTH injection?

ACTH is a hormone produced by the pituitary gland in the brain. This medicine is injected into the thigh muscle to reduce infantile spasms. Infantile spasms (IS) is a type of epilepsy that usually occurs in babies and is often associated with development problems.