What is SSA and SSB blood test?

INTRODUCTION. Anti‐SSA and ‐SSB antibodies are clinically important antinuclear antibody (ANA) in patients with systemic rheumatic diseases. These antibodies are found in Sjögren’s syndrome (SS), as well as other systemic autoimmune diseases (ADs), such as systemic lupus erythematosus (SLE), myositis, scleroderma, etc.

What does a positive SSA and SSB antibody mean?

A positive result for SSA (Ro) or SSB (La) antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis.

What does SSB blood test mean?

Anti-Sjögren’s syndrome type B (SSB) antibodies are one of the most common autoantibodies in the serum of SLE patients and also one of the earlier autoantibodies to be produced (11–13).

What does a positive Sjogren’s antibody test mean?

What does it mean to have elevated Sjögren’s antibodies? Elevated Sjögren’s antibodies—anti-SS-A and anti-SS-B—are suggestive of inflammatory connective tissue disease. Elevated results on this test may indicate Sjögren’s syndrome or another autoimmune disease such as lupus or rheumatoid arthritis.

Does positive SS-A mean lupus?

In pregnant women, a positive Anti-Ro(SSA) or Anti-La(SSB) warns doctors of the need to monitor the unborn baby. Limitations of the test: Like other antibodies, the fact that the test is not positive in many people with lupus means it can’t be used to diagnose lupus.

Can you have sjogrens with negative SS-A and SS-B?

Highlights. Sjögren’s syndrome negative for anti-SSA/SSB antibodies, showed a lower risk of lymphoma. Sjögren’s syndrome negative for anti-SSA/SSB showed a lower prevalence of salivary gland swelling or purpura. Younger patients with anti-SSA/SSB and rheumatoid factor showed the highest risk of lymphoma.

What labs are abnormal with Sjögren’s syndrome?

Many patients with Sjögren’s have one of two specific abnormal auto-antibodies that can be detected in their blood: anti-SSA and anti-SSB, also known as “anti-Ro” and “anti-La.” Most hospitals and doctors’ offices can send patients’ blood for these tests.

What happens if Sjögren’s is left untreated?

Sjogren’s comes with serious complications if left untreated, including: an increased risk of lymphoma and multiple myeloma. oral yeast infections. dental cavities.