What is SSA and SS-B antibody?

Anti‐SSA and ‐SSB antibodies are clinically important antinuclear antibody (ANA) in patients with systemic rheumatic diseases. These antibodies are found in Sjögren’s syndrome (SS), as well as other systemic autoimmune diseases (ADs), such as systemic lupus erythematosus (SLE), myositis, scleroderma, etc.

What is Sjogren’s AB anti SS A /- SS-B?

The Sjogren’s Anti SS-A and SS-B Blood Test aids in the diagnosis of Sjögren’s syndrome (especially with vasculitis) and lupus patients with Sjögren overlap syndrome. Preparation: No special preparation required.

Can Sjogren’s antibodies go away?

Secondary Sjogren’s syndrome develops in a person who has another autoimmune disease, usually rheumatoid arthritis or lupus. Treatment for both types is the same. There is no cure for Sjogren’s syndrome, but treatment can address symptoms and improve quality of life.

What does a positive SS-A antibody mean?

A positive result for SSA (Ro) or SSB (La) antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis.

What is Sjögren’s antibody SS A?

The presence of anti-Ro(SS-A) antibodies defines a subset of patients with Sjögren’s syndrome who have systemic clinical manifestations including vasculitis, hematologic abnormalities, and serologic hyperreactivity.

Is Sjögren’s a form of lupus?

Sjogren’s syndrome has a very slow, insidious onset. About 90% of individuals with Sjogren’s symptoms are women, and the syndrome tends to aggregate to older individuals. Unlike lupus, Sjogren’s afflicts all races equally.

What does a positive SS-B/La antibody test mean?

A positive result for SS-B/La antibodies is consistent with connective tissue disease, including Sjogren syndrome and lupus erythematosus. See Connective Tissue Disease Cascade (CTDC) in Special Instructions.

What are Anti-Sjögren’s syndrome type B (SSB) antibodies?

Anti-Sjögren’s syndrome type B (SSB) antibodies are one of the most common autoantibodies in the serum of SLE patients and also one of the earlier autoantibodies to be produced (11–13).

What is the molecular weight of the SSB antigen?

The molecular weight of the SSB antigen is 48,000, it is highly conserved in evolution and is involved in regulating RNA polymerase III and mRNA transcription. Amino acid sites 80–100, 220–240 and 300–340 in the SSB molecule have a strong antigenicity (19).

Is the Anti-SSB antibody associated with systemic stress syndrome (SSS)?

The present study identified that the incidence of sSS varies between the anti-SSB antibody-positive and negative groups, strongly suggesting that the anti-SSB antibody is associated with sSS.