What is specific immunodeficiency?

Specific antibody deficiency (SAD) is a primary immunodeficiency disease (PIDD) characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination (1–3).

What are the types of immunodeficiency?

There are two types of immunodeficiency disorders: those you are born with (primary), and those that are acquired (secondary). Anything that weakens your immune system can lead to a secondary immunodeficiency disorder.

What are the symptoms of specific antibody deficiency?

People with selective antibody deficiency do not produce antibodies in response to polysaccharide vaccines. Affected people have many sinus and lung infections and sometimes symptoms of allergies, such as a chronic runny and stuffy nose (rhinitis), a rash, and asthma. The severity of the disorder varies.

What are the PI diseases?

Signs and symptoms of PI

  • Ear infections.
  • Sinus infections.
  • Pneumonia.
  • Bronchitis.
  • Meningitis.
  • Skin infections.
  • Thrush (a fungal infection of the mouth or skin, also called candidiasis)

What are the common symptoms of CVID?

What are the symptoms of common variable immunodeficiency (CVID)?

  • Breathing problems.
  • Chronic cough.
  • Diarrhea that causes weight loss.
  • Ear infections.
  • Frequent sinus infections.
  • Recurring lung infections, including pneumonia.

How is CVID diagnosis?

The diagnosis of CVID is primarily established by testing for low blood (serum) IgG immunoglobulin concentrations ranging from severely reduced (<100 mg/dL) to just below adult normal range (500-1200 mg/dL). In addition, laboratory testing may reveal normal or, in some cases, reduced numbers of circulating B cells.

Is diabetes an immunodeficiency?

The short answer? No, people with diabetes are not immunocompromised, and they are not at a higher risk of contracting COVID-19.

What is the life expectancy of someone with CVID?

The life expectancy of CVID patients has considerably improved over the past 30 years [5, 63], from initially 12 years to currently over 50 years [3]. Reduced survival was significantly associated with age at diagnosis, lower baseline IgG, higher IgM and fewer peripheral B cells.

How is PI diagnosed?

PI is diagnosed in several ways When testing for PI, doctors will ask about family history and do a physical exam. They will also order blood tests to check if blood cells, antibodies, and the immune system are working properly. These tests are important to confirm a diagnosis and the type of PI.

What is a PI baby?

When a child is diagnosed with a primary immunodeficiency disease, each member of the family begins an unexpected and challenging journey. The whole family must come to terms with the illness and perhaps make major changes in schedules and priorities.

Can CVID be cured?

CVID has no cure. With ongoing treatment, many people with the disorder live active and fulfilling lives. In some cases, complications of CVID such as lung damage or cancer may affect life expectancy. These complications appear over time.