What is SCOP and CATH?

What is SCOP and CATH?

SCOP and CATH are hierarchical domain classification systems. Domains within the same SCOP superfamily have structural and functional similarities that suggest a common evolutionary origin but may not share a detect- able sequence similarity. The equivalent CATH category is the ”Homologous Superfamily” (H-level).

How many levels of SCOP are?

SCOP Hierarchy Four levels of SCOP are shown: fold, superfamily, family, and sequence (dark blue rectangles). The number of sequences is equal to or greater than the number of families, which is equal to or greater than the number superfamilies, which in turn is equal to or greater than the number of folds.

What are the different levels of structural classification in SCOP?

SCOP is organised as a tree structure. Entering at the top of the hierarchy the user can navigate through the levels of Class, Fold, Superfamily, Family and Species to the leaves of the tree which are structural domains of individual PDB entries.

What is CATH in biochemistry?

CATH is a classification of protein structures downloaded from the Protein Data Bank. We group protein domains into superfamilies when there is sufficient evidence they have diverged from a common ancestor.

What is SCOP and FSSP?

The most widely used and comprehensive databases are SCOP, CATH and FSSP, which represent three unique methods of classifying protein structures: purely manual, a combination of manual and automated, and purely automated, respectively.

What is SCOP domain?

The Structural Classification of Proteins (SCOP) database is a largely manual classification of protein structural domains based on similarities of their structures and amino acid sequences. A motivation for this classification is to determine the evolutionary relationship between proteins.

What is Cath in bioinformatics?

The CATH database[3,4] is a classification of protein domains (sub-sequences of proteins that may fold, evolve and function independently of the rest of the protein), based not only on sequence information, but also on structural and functional properties.

What is CATH in bioinformatics?

What is CATH full form?

CATH (see “Relevant Websites section”) Protein structures are classified using a combination of automated and manual procedures. There are four major levels in this hierarchy which are Class, Architecture, Topology, and Homologous superfamily.

Is SCOP a secondary database?

The SCOP database is freely accessible on the internet. SCOP was created in 1994 in the Centre for Protein Engineering and the Laboratory of Molecular Biology….Structural Classification of Proteins database.

What is topology in CATH?

This level of the CATH hierarchy describes structures that are grouped according to whether they share the same topology or fold in the core of the domain, that is, if they share the same overall shape and connectivity of the secondary structures in the domain core.

Is SCOP a primary database?

The SCOP database is freely accessible on the internet. SCOP was created in 1994 in the Centre for Protein Engineering and the Laboratory of Molecular Biology. It was maintained by Alexey G….Structural Classification of Proteins database.