What is renal allograft dysfunction?

ALLOGRAFT DYSFUNCTION AND HISTOPATHOLOGY. Kidney graft dysfunction is defined as an increase in serum creatinine of 15% from baseline, which is often the primary indicator for biopsy. Other indicators for biopsy include oliguria and proteinuria.

What is the major cause of allograft failure?

Conclusion: The main causes of allograft loss were antibody-mediated rejection and thrombosis. These results encourage efforts to prevent and detect these complications earlier in order to improve allograft survival.

What is renal allograft rupture?

Renal allograft rupture (RAR) is a rare but lethal complication of renal transplantation. It potentially threatens graft and patient survival. RAR is frequently associated with acute rejection, but other causes like renal vein thrombosis and acute tubular necrosis have also been observed.

What is acute renal allograft rejection?

Acute renal allograft rejection is a major cause of allograft dysfunction. Some kidneys do not regain function even with maximal antirejection therapy. Even among patients who recover, acute rejection episodes can have a negative impact on long-term graft survival.

What are the leading causes of acute kidney allograft transplant dysfunction?

Sepsis and infections can lead to development of acute tubular injury and graft dysfunction. By far the most common viral cause of allograft dysfunction is BK virus infection.

What is meant by allograft?

Listen to pronunciation. (A-loh-graft) The transplant of an organ, tissue, or cells from one individual to another individual of the same species who is not an identical twin.

What is chronic allograft dysfunction?

Chronic allograft dysfunction (CAD) is a multifactorial process associated with progressive interstitial fibrosis and tubular atrophy.

When was the first kidney transplant in the UK?

Following the introduction of the National Health Service in 1948, the UK’s first successful kidney transplant was carried out in 1960. The transplant was carried out in Edinburgh by Sir Michael Woodruff, as an identical twin acted as a living donor for his brother.

What is the gold standard for diagnosis of allograft rejection?

The current gold standard for the rejection diagnosis is an allograft biopsy which is usually performed upon an unexplained decline in allograft function. Because of the invasiveness of the biopsy, non-invasive tests have been suggested to diagnose acute rejection including mass spectrometry analysis of urine samples.

What are the signs and symptoms of kidney transplant rejection?

Signs and Symptoms of Acute Rejection

  • Tenderness or pain over the kidney transplant.
  • A general achy feeling.
  • Swelling in the hands and feet.
  • An elevated temperature.
  • A rapid weight gain.
  • An increase in blood pressure.
  • An increase in blood creatinine.
  • A decrease in urine output.

Which condition is the most common cause of renal graft failure?

The most frequent cause of DWFG in the US is cardiovascular disease [16, 17, 19]. With few diabetic and elderly patients, the number of Kurdistan transplant recipients at risk for cardiovascular-related DWFG is small.

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