What is precocious Pseudopuberty?

In precocious pseudopuberty, the excess secretion of sex hormones occurs from the gonads, adrenal glands, ectopic or exogenous sources. This process does not depend on the activation of the hypothalamic-pituitary-gonadal axis and is associated with suppressed levels of GnRH, FSH, and LH.

What is premature Pubarche?

Pubarche is the physical manifestation of adrenarche and is characterized by the development of pubic hair, axillary hair, adult apocrine body odor, acne, and increased oiliness of hair and skin. Pubarche is considered premature if it develops before age eight years in girls and nine years in boys.

What causes precocious puberty?

What causes precocious puberty? It may be caused by tumors or growths on the ovaries, adrenal glands, pituitary gland, or brain. Other causes may include central nervous system problems, family history of the disease, or certain rare genetic syndromes. In many cases, no cause can be found for the disorder.

What causes premature adrenarche?

What causes premature adrenarche? Premature adrenarche is caused when the adrenal gland begins secreting sex hormones called androgens earlier than normal. In most cases, it’s not that more androgen is being made, it’s that the standard amount is being made earlier than normal.

What is the difference between precocious puberty and premature adrenarche?

Premature thelarche is the appearance of breast development in young girls in the absence of other signs of precocious puberty (eg, growth acceleration, changes in uterine size and vaginal mucosa). Premature thelarche is typically seen in girls aged 3 years or younger.

Why does my 5 year old daughter have pubic hair?

Premature pubarche, or the development of pubic hair before the age of 8 in girls or 9 in boys, is most commonly caused by premature adrenarche. Adrenarche is the maturation of the adrenal zona reticularis in both boys and girls, resulting in the development of pubic hair, axillary hair, and adult apocrine body odor.

Can you reverse precocious puberty?

Sometimes, treatment of a related health problem can stop the precocious puberty. But in most cases, there’s no other disease, so treatment usually involves hormone therapy to stop sexual development. The currently approved hormone treatment is with drugs called LHRH analogs.

Does premature adrenarche cause advanced bone age?

Background: Premature adrenarche (PA) is often associated with bone age (BA) advanced by ≥2 years, which increases the concern for underlying pathology, but the frequency and clinical significance of this is unknown.

Does premature adrenarche affect height?

Advanced prepubertal growth in height has been reported in most premature adrenarche cohort studies. One possible link between accelerated statural growth and premature adrenarche is insulin-like growth factor 1 (IGF-1) whose increased concentrations have been found in premature adrenarche children.