What is plasma cell cheilitis?

Plasma cell cheilitis (PCC) is an inflammatory disorder of unknown etiology that affects the lip. It is characterized histologically by a dense infiltrate of plasma cells with a variety of clinical features.

What causes cheilitis Glandularis?

Cheilitis glandularis is an uncommon condition in the United States. However, factitial injury to the lower lip vermilion border and mucosa due to chronic lip biting, lip drying, or habitual lip licking, combined with sun-induced lip damage, are extremely commonplace.

What is plasma cell mucositis?

Plasma cell mucositis (PCM) is a benign inflammatory condition characterized by dense plasma cell infiltrate in the mucosa close to the orifices. PCM was first reported by Zoon [1] as involving glans penis.

What is granulomatous cheilitis?

Granulomatous cheilitis (GC) is a rare disorder characterized by noncaseating granulomatous inflammation of the lips in the absence of systemic disease, eg, Crohn disease (CD) or sarcoidosis.

What are the types of cheilitis?

Types of cheilitis

  • Herpes simplex.
  • Angular cheilitis.
  • Granulomatous cheilitis.
  • Orofacial granulomatosis.
  • Crohn skin disease.
  • Actinic cheilitis.
  • Exfoliative cheilitis.
  • Glandular cheilitis.

How is cheilitis Glandularis treatment?

Treatment options for cases of actinic cheilitis with moderate-to-severe dysplasia include surgical stripping or vermilionectomy, cryosurgery or laser surgery, or topical chemotherapy with 5-fluorouracil.

What is cheilitis skin?

Cheilitis is an inflammation of the lips. It may be acute or chronic, involving the vermilion and/or surrounding skin of one or both lips.

How does actinic cheilitis start?

Actinic cheilitis is a type of precancerous skin change that happens on the lips. It is usually related to damage from sun exposure or tanning beds. This condition can develop into a kind of skin cancer called squamous cell carcinoma if you do not have it treated.

What is cheilitis simplex?

Cheilitis simplex (chapped lips, common cheilitis, cheilitis sicca) is one of the most common subtypes, presenting as cracked lips, fissures or desquamation of the lips, usually of the lower lip (Fig. 1) (2, 7). Here frequent lip licking promotes dryness and irritation, ending in separation of the mucosa and cracking.

What do we know about plasmapheresis cheilitis?

Plasma cell cheilitis is an unusual benign plasma cell proliferative disease of an unknown etiology that typically presents on the lip. Objective The aim of this study was to investigate the clinicopathological characteristics of 13 cases of plasma cell cheilitis. Methods

How is plasma-cell cheilitis (PCC) treated?

Plasma-cell cheilitis: successful treatment with intralesional injections of corticosteroids. Clin Exp Dermatol 2009;34:174–177. 13. Yoshimura K, Nakano S, Tsuruta D, Ohata C, Hashimoto T. Successful treatment with 308-nm monochromatic excimer light and subsequent tacrolimus 0.03% ointment in refractory plasma cell cheilitis.

What are plaques in plasmacytoma cheilitis?

Plasma cell cheilitis presented as erosive edematous circumscribed patches or plaques affecting mainly the lower lip of elderly male patients. The majority of histopathology cases showed characteristic plasma cell aggregation on the upper dermis that was immunopositive for immunoglobulin light chain, with kappa predominance.

What is the pathophysiology of plasma cell infiltration?

Although the pathogenesis for the plasma cell infiltration remains unknown, B-cell growth and differentiation in the mucosa and skin are suggested to be affected by T cells and macrophages1,6,7.