What is pan-genome concept?

The pan-genome represents the entire set of genes within a species, consisting of a core genome — containing sequences shared between all individuals of the species — and the ‘dispensable’ genome.

What is unique about Streptococcus pyogenes?

Streptococcus pyogenes (group A streptococcus; GAS) is unique among human pathogens in its ability to cause a wide variety of clinical infections and postinfectious sequelae. Further, in its coevolution with humans, GAS has developed a myriad of molecular strategies to circumvent important host defense mechanisms.

What is the difference between a core and pan-genome?

The core-genome is the set of homologous genes that are present in all genomes of an analyzed dataset and the pan-genome is the set of all genes that are present in the analyzed dataset [16].

Does Streptococcus pyogenes have DNA?

pyogenes genome is as follows: the genome is composed of a single chromosome that is approximately 1.8-Mbp long with a GC content of 38.5 ± 0.1% on average, and includes 1,826 ± 92 protein-coding regions (CDSs), 5 or 6 rRNA operons, and from 57 to 67 tRNA encoding genes.

How is the pan-genome differentiated for a given species?

The official source is the International Journal of Systematic and Evolutionary Microbiology. How is the pan genome differentiated for a given species? The pan genome is in addition to the core genome and only found in some members of a given species.

What is a closed pan-genome?

A closed pangenome occurs in a lineage when only few gene families are added when new genomes are incorporated into the pangenome analysis, and the total amount of gene families in the pangenome seem to be asymptotic to one number.

How do you identify Streptococcus pyogenes?

To identify S. pyogenes in clinical samples, blood agar plates are screened for the presence of β-hemolytic colonies. The typical appearance of S. pyogenes colonies after 24 hours of incubation at 35-37°C is dome-shaped with a smooth or moist surface and clear margins.

What is the only known reservoir for Streptococcus pyogenes?

It resists phagocytosis and produces an erythrogenic toxin that causes scarlet fever. Streptococcus agalactiae belongs to group B streptococci (GBS) and is an important agent of bovine mastitis in some countries and a cause of diseases in humans. The gastrointestinal tract is the main human reservoir.

What is the pathogenesis of Streptococcus pyogenes?

Streptococcus pyogenes (group A streptococcus) is an important species of gram-positive extracellular bacterial pathogens. Group A streptococci colonize the throat or skin and are responsible for a number of suppurative infections and nonsuppurative sequelae.

What comprises the Pan genome of a given species quizlet?

The core genome is a set of genes shared by all members of a species, while the pan genome includes the core genes as well as genes that are not shared by all members.