What is NS1 positive in dengue test?
What is NS1 positive in dengue test?
A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.
What is dengue IgM and IgG and NS1?
Dengue Antigen NS1, IgG and IgM test detects the non-structural protein component (NS1) of the dengue virus and the antibodies (IgG & IgM) produced by the body in response to the infection. NS1 and IgM is secreted into the blood during dengue infection and are detectable within 3-4 days of illness.
Is dengue NS1 test accurate?
The accuracy of the NS1 antigen rapid test is considered high with sensitivity 55%-82% and specificity 97%-100%. Since the NS1 rapid test aims to detect dengue NS1 antigen, it should be performed within 5 days of onset of fever.
What is dengue NS1 full form?
Detection of the dengue virus nonstructural protein 1 (NS1) antigen is suggestive of recent exposure and/or acute infection with dengue virus. This test should be used for diagnostic purposes only. Dengue NS1 antigenemia overlaps with dengue virus viremia and can be used as an acute phase marker for infection.
Which test is best for dengue?
Molecular testing (polymerase chain reaction, PCR)—this type of test detects the genetic material of the dengue virus in blood within the first week after symptoms appear (fever) and can be used to determine which of the 4 serotypes is causing the infection.
What is normal value of NS1 antigen?
An NS1 Ag level varies from 0.5-2 μg/ml in acute-phase serum samples, to less than 0.04 μg/ml in convalescent phase serum [11]. The requirement of paired sera, subsequently in convalescent phase, if negative in acute phase also delays diagnosis.
What is difference between dengue NS1 and IgM?
NS1 antigen is generally found during Day 1 and up to Day 9 after onset of fever. The detection of anti-NS1 is inhibited if anti-NS1 antibodies produced. Whereas IgM become detectable by Day 3 to Day 5 after onset of illness in primary dengue and by Day 1 to Day 2 after onset of illness in secondary infections.
What if IgM is positive and IgG is negative in dengue?
If the IgG is positive but the IgM is low or negative, then it is likely that the person had an infection sometime in the past….
| IgM Result | IgG Result | Possible Interpretation |
|---|---|---|
| Positive | Negative | Current infection |
| Positive | Positive | Current infection |
When should NS1 test be done?
Avinash Phadke Labs, “The NS1 test should be taken on the very first day of the fever striking. It holds relevance after 24 hours also, but ideally should be taken within 24 hours.”
Can CBC test detect dengue?
The clinical presentation of dengue patients is acute febrile illness with no localizing signs and symptoms which may mimic other infections. Therefore the laboratory tests such as a complete blood count (CBC), serological test or blood culture need to be used to differential and confirm the diagnosis.
What is dengue IgG and IgM test?
Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that the person became infected with dengue virus within recent weeks. IgM antibody tests can be positive if a person has been infected with a similar virus, such as chikungunya (called cross-reaction).
Is NS1 test done empty stomach?
Dengue rapid test may be conducted any time of the day without fasting. However, if you are on medications, it is advisable to inform your doctor about them.
