What is Nonseminomatous testicular cancer?

Non-seminomatous germ cell tumors are associated with male infertility due to low sperm counts, reduced sperm motility, and increased abnormal morphology. This is thought to be due to spermatogenesis abnormalities and has been reported in up to 35% of patients with NSGCT.

What is a Nonseminomatous germ cell tumor?

Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. They originate from cells that were meant to form sex cells (i.e., sperm or eggs).

What is the most common testicular germ cell tumor?

Two of the most common germ cell tumors are seminoma and nonseminoma. Seminomas make up about half of all germ cell tumors. They usually grow slowly. Our doctors can often cure early-stage seminomas because they’re less likely to metastasize (spread) to other parts of the body.

What is germ cell testicular cancer?

More than 90% of testicular cancer start in the germ cells, which are cells in the testicles and develop into sperm. This type of cancer is known as testicular germ cell cancer. Testicular germ cell cancer can be classified as either seminomas or nonseminomas, which may be identified by microscopy.

What is the survival rate of germ cell tumor?

The cure rates are approximately 90% for Stage I, 90% for Stage II, 87% for Stage III, and 82% for Stage IV.

Which tumor is the most aggressive of testicular cancers?

Embryonal carcinoma: present in about 40 percent of tumors and among the most rapidly growing and potentially aggressive tumor types. Embryonal carcinoma can secrete HCG or alpha fetoprotein (AFP).

Is germ cell tumor curable?

Germ cell tumours generally respond very well to chemotherapy. Most people are cured. Even cancers that have spread are still very treatable with chemotherapy.

Which of the following is a tumor marker of Nonseminomatous germ cell tumors?

Serum hCG and AFP are the most important tumor markers. AFP levels are elevated in 50-70% of patients with NSGTs, and hCG levels are elevated in 40%-60%.

What causes germ cell Tumours?

The cause of most germ cell tumors isn’t always known. Doctors do know that some medical conditions can make children more likely to develop them. These include: birth defects that involve the central nervous system, genitals, urinary tract, and spine.