What is neurofilament light chain NfL responsible for?

The protein neurofilament light chain (NfL) is a key component of axons — myelinated nerve segments responsible for the transmission of nerve signals — and the main byproduct of nerve cell degeneration.

What is a neurofilament test?

The Neurofilament Light (NFL) assay is a laboratory developed test (LDT) used to quantify neurofilament light chain (NFL) in human serum, plasma or CSF using the Atellica® Immunoassay system.

What is serum NfL?

Serum NfL (sNfL) is a plausible marker of neurodegeneration that can be measured accurately, sensitively, and reproducibly, but standard procedures for sample processing and analysis should be established.

Where is neurofilament located?

cytoplasm
Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter and many micrometers in length. Together with microtubules (~25 nm) and microfilaments (7 nm), they form the neuronal cytoskeleton.

What is NfL biology?

Neurofilament light chain is a biomarker that can be measured with immunoassays in cerebrospinal fluid and plasma and reflects axonal damage in a wide variety of neurological disorders.

Is neurofilament light a protein?

Neurofilament light protein (NfL, also known as NF-L) is the smallest of three subunits that make up neurofilaments, which are major components of the neuronal cytoskeleton.

What is serum neurofilament light chain?

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.

What is NfL biomarker?

A promising biomarker in neurodegenerative diseases is the neurofilament light chain protein (NfL), which provides a sensitive measurement of neuroaxonal damage, regardless of cause. NfL in CSF (cNfL) was higher in patients with PD compared with healthy controls in some but not all studies.

Where are Vimentins found?

Vimentin intermediate filaments are generally present in mesenchymal cells. Vimentin is found not only in eukaryotic cells, but also in bacteria, where it helps to form the cytoskeleton. Vimentin is encoded by the VIM gene and has 466 amino acids.

Do neurofilaments have polarity?

As a result of this antiparallel arrangement, NFs lack polarity, unlike the polar structure of MTs and actin filaments, which have two distinct ends.

What is desmin used for?

Desmin is the major intermediate filament in skeletal, cardiac, and in some smooth muscle cells and it is important in the maintenance of cytoskeletal integrity by linking Z bands to the plasma membrane.

Is vimentin a Microfilament?

Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all animal cells as well as bacteria. Intermediate filaments, along with tubulin-based microtubules and actin-based microfilaments, comprises the cytoskeleton.