What is multiple exostosis?

Description: Hereditary multiple exostosis is a benign disorder characterized by multiple chondrogenic lesions (osteochondromas) found on the surfaces of bones, often at the sites of tendon insertions. They are most commonly found in the proximal femur, distal femur, proximal tibia, and the proximal humerus.

Is there a cure for hereditary multiple exostoses?

At present, there is no treatment to prevent, reduce or reverse the formation of osteochondromas [5, 6]. Most HME cases are linked to heterozygous loss-of-function mutations in the tumor suppressor genes EXT1 or EXT2 that encode Golgi glycosyl-polymerases responsible for the synthesis of heparan sulfate (HS) [7, 8].

How common is hereditary multiple exostoses?

The prevalence of HMO has been estimated to be about 1 of 50,000 live births. A high prevalence of this disorder has been reported in some isolated communities. Hereditary multiple osteochondromas is a disorder that affects males and females in equal numbers but in general males tend to be more severely affected.

Is multiple Exostoses a disease?

Abstract. Multiple exostosis disease is one of the hereditary diseases with autosomal dominant transmission. It is characterized by the proliferation of bone protuberances, especially located in the metaphysis of long bones.

What is familial exostosis?

What is hereditary multiple exostosis? Hereditary multiple exostosis, also known as diaphyseal aclasis, is a genetic condition often passed down to a child by one parent, but it can also be caused by a genetic mutation, meaning it can occur on its own by a change.

Why does exostosis happen?

The causes of exostosis depend on the type and location of the bone overgrowths. Common causes include injury, chronic irritation of a bone, or a family history of exostosis. In some cases, the cause of exostosis is unknown.

How do you get rid of exostosis?

An exostosis may require no treatment at all. But in some cases, treatment may be necessary. For surfer’s ear: In more serious cases, surfer’s ear can be treated by an operation known as canalplasty. Wearing ear plugs or a head covering may be a way for surfers to avoid this type of exostosis.