What is microRNA 146a?

MiR-146a is a miRNA supposed to regulate innate immune, inflammatory response and antiviral pathway negatively. In this review, we focus on the recent progress in functional role of miR-146a in innate immune, inflammatory response, virus infection and human diseases.

Is Lin 4 a microRNA?

In molecular biology lin-4 is a microRNA (miRNA) that was identified from a study of developmental timing in the nematode Caenorhabditis elegans. It was the first to be discovered of the miRNAs, a class of non-coding RNAs involved in gene regulation.

What is HSA miRNA?

The “hsa” tells us it is a human miRNA. The “20″ tells us that was discovered early — it’s only the 20th family that was named. “20b” tells us that it is related to another miRNA that we can guess is probably called hsa-mir-20a.

How do you quantify microRNA?

Currently, quantitative real-time PCR (qPCR), microarray, and next-generation sequencing (NGS) are the most commonly used techniques for quantifying miRNA. While such procedures are routinely used in the laboratory, not one is completely ideal for rapid, reproducible miRNA detection.

What does Lin 4 miRNA bind to?

lin-4 is turned “on” at the end of the first of 4 larval stages (late L1) and binds to complementary regions in the 3′UTR of lin-14 and lin-28 to suppress their expression. Proper timing of lin-4 expression is critical to control the transition between the first and second larval stages during the nematode life cycle.

What type of protein is Lin-14?

nuclear protein
“The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch.”

What is 3p and 5p in miRNA?

In the precursor miRNA stem loop structure, the 5p strand is present in the forward (5′-3′) position and 3p strand (which will be almost complimentary to the 5p strand) is located in the reverse position.