What is metabolon platform?

Metabolon’s Precision Metabolomics™ LC-MS global metabolomics platform provides a high-fidelity, reproducible analysis of the current-state of a biological system to help identify pharmacodynamic, efficacy and response biomarkers and reveal changes in key biological pathways.

Where is metabolon located?

Research Triangle Park, North Carolina
Founded in 2000 and based in Research Triangle Park, North Carolina, Metabolon has conducted more than 10,000 independent and collaborative studies, resulting in 2,000+ publications in leading peer-reviewed journals. For more information about our technology, products and services, please visit www.metabolon.com.

What is the gut Metabolome?

Metabolomics has emerged as a technique that focuses on defining the functional status of host–microbial relationships in biological specimens, such as urine, blood, feces and tissues. Most studies on the gut microbiome aim to explore disease-related metabolites or dysregulated metabolic pathways (Fig.

How many metabolites are there?

The Human Metabolome Database The chemical data includes >40,000 metabolite structures with detailed descriptions, extensive chemical classifications, synthesis information and observed/calculated chemical properties.

What is metabolon formation?

Metabolon formation typically involves specific interactions between several ‘soluble’ enzymes that might be anchored to a membrane either by membrane-bound structural proteins that serve as ‘nucleation’ sites for metabolon formation or by membrane-bound proteins, such as cytochrome P450s (CYPs), that directly catalyze …

How do Metabolons work?

The formation of metabolons allows the intermediate product from one enzyme to be passed (channelling) directly into the active site of the next consecutive enzyme of the metabolic pathway. The citric acid cycle is an example of a metabolon that facilitates substrate channeling.

What is the study of metabolomics?

Metabolomics is the large-scale study of small molecules, commonly known as metabolites, within cells, biofluids, tissues or organisms. Collectively, these small molecules and their interactions within a biological system are known as the metabolome.

What are metabolites made of?

Metabolites can be defined as endogenous compounds such as amino acids, lipids, sugars, organic acids, etc., which are routinely being formed in the anabolism or catabolism process.

What are examples of metabolites?

Examples of primary metabolites are ethanol, glutamic acid, aspartic acid, 5′ guanylic acid, acetic acid, lactic acid, glycerol, etc. Examples of secondary metabolites are pigments, resins, terpenes, ergot, alkaloids, antibiotics, naphthalenes, nucleosides, quinolones, peptides, growth hormones, etc.

What is metabolon biochemistry?

The metabolon is a transient structural–functional substrate channel formed among sequential enzymes of a metabolic pathway and is associated with non-covalent interactions and structural elements of the cell, such as integral membrane proteins and cytoskeletal proteins (Srere, 1985; Møller, 2010).

Why is metabolomics used?

Metabolomics is an objective lens to view the complex nature of how physiology is linked to external events and conditions, as well as measure its response to perturbations such as those associated with disease.

What are the applications of metabolomics?

At present, metabolomics is applied to investigate several human diseases, to improve their diagnosis and prevention, and to design better therapeutic strategies. In addition, metabolomic studies are also being carried out in areas such as toxicology and pharmacology, crop breeding, and plant biotechnology.