What is meant by stability of a coordination compound in solution?

The stability of a coordination compound (aq) means the degree of association between the two species involved in the state of equilibrium. The magnitude of (stability or formation ) equilibrium constant for the association; quantitative expresses the stability. For a reaction, M + 4L → ML4.

How is the stability of a coordination compound in solution decided?

(i) Charge on the central metal ion: In general, the greater the charge density on the central ion, the greater is the stability of its complexes. The greater the charge and the smaller the size of an ion, i.e., (the larger the charge/radius ratio of an ion), the greater is the stability of its complex.

How coordination compounds are used in medicine?

Coordination compounds such as platinum, palladium and ruthenium complexes are anti-cancer drugs. Also, many of the coordination compounds are anti-bacterial. The coordination compounds have been showed effective behaviour against many diseases like Alzheimer’s and malaria.

What are the factors that affect the stability of the coordination complexes?

There are several factors that can affect the stability of the metal complexes [2, 5, 8, 9], which include:

  • Nature of the central metal ion.
  • Nature of the ligand.
  • Chelating effect.
  • Macrocyclic effect.
  • Resonance effect.
  • Steric effect or steric hindrance.

How stability of the coordination compounds can be explained in terms of equilibrium constant?

The stability of the complex can be explained in terms of K. Higher the value of K larger is the thermodynamic stability of the complex. The equilibria for the complex formation with the corresponding K values are given below.

What is the role of coordination compound in biological system?

(i) Role of coordination compounds in biological systems: This pigment is a coordination compound of magnesium. In the human biological system, several coordination compounds play important roles. For example, the oxygen-carrier of blood, i.e., haemoglobin, is a coordination compound of iron.

What contributes to the stability of a compound?

The stability of the compounds depends on the energy of sublimation, the lattice energy and the solvation energy.

What are the applications of coordination compounds in biology and medicine?

Many coordination complexes have been used in medicine containing metals such as platinum (cisplatin as anticancer chemotherapy drug), gold (as auranofin used for rheumatoid arthritis), technetium and rhenium (as radiopharmaceuticals used in imaging and radiotherapy), ruthenium (as anticancer drug), gadolinium, cobalt.

What is the importance of coordination compounds?

Coordination compounds are used as catalysts for many industrial processes and have many applications in qualitative/quantitative chemical analysis within analytical chemistry. The of coordination compounds has importance in biological system, the coordination compounds play a vital role in metallurgy and medicine.

What are the factors that affect stability?

Common factors that affect this stability include temperature, light, pH, oxidation and enzymatic degradation. Special considerations are also required when dealing with chiral molecules, deuterated internal standards and large biomolecules.

What is meant by stability constant?

A stability constant (formation constant, binding constant) is an equilibrium constant for the formation of a complex in solution. It is a measure of the strength of the interaction between the reagents that come together to form the complex.