What is mean by disintegrating agent?

A disintegrant is an agent, used in the preparation of tablets, which causes them to disintegrate and release their medicinal substances on contact with moisture. We evaluated the disintegrants by timing how long the tablets took to disintegrate. Disintegrants help a tablet to break up after oral administration.

What is a Disintegrant?

A disintegrant is an additive that promotes disintegration, which is the breakage of a tablet into small fragments when in contact with a liquid medium. In doing so, the surface area available for dissolution is increased and drug dissolution is accelerated.

What is the meaning of ODTs?

An orally disintegrating tablet or orally dissolving tablet (ODT) is a drug dosage form available for a limited range of over-the-counter (OTC) and prescription medications. ODTs differ from traditional tablets in that they are designed to be dissolved on the tongue rather than swallowed whole.

What is Superdisintegrants?

Superdisintegrants: Disintegrating agents are substances routinely included in the tablet formulations to aid in the break-up of the compacted mass into the primary particles to facilitate the dissolution or release of the active ingredients when it is put into a fluid environment.

What is disintegrating used for?

ORALLY DISINTEGRATING TABLETS (ODTs) dissolve or disintegrate in the mouth without water within 60 seconds when placed on the patient’s tongue. They’re ideal for patients such as children or older adults who have difficulty swallowing traditional oral tablets or capsules and those with mental illness.

What is intragranular and Extragranular?

Abstract. When a tablet is compacted from deformable granules and then broken, the fracture plane may cleave granules in 2 (intragranular fracture) or separate neighboring granules (extragranular fracture).

Does ODT mean under the tongue?

An ODT is a solid dosage form that disintegrates and dissolves in the mouth (either on or beneath the tongue or in the buccal cavity) without water within 60 seconds or less.

What is a caplet?

Definition of caplet : a capsule-shaped medicinal tablet. Note: The name Caplets was formerly a U.S. registered trademark.

Why are Superdisintegrants used?

Superdisintegrants are used as a structural weakener for the disintegrable solid dosage forms. They are physically dispersed within the matrix of the dosage form and will expand when the dosage form is exposed to the wet environment 21.

How do disintegrants work?

Disintegrants are added to tablet to induce breakup when it comes in contact with aqueous fluid. Disintegration by capillary action or by swelling is the major mechanism for disintegrants. Disintegrant can be added intragranular or extragranular or at both stages.

What are granulating agents?

A granulating agent provided proper moisture to convert fine powder into damp mass ,which after passing through a sieve of suitable number forms granules. The various granulating agents used are water,alcohol,mucilage of starch,mucilage of acacia ,mucilage of tragacanth,gelatin solution,iso-propyl alcohol,acetone etc.

What is Extragranular?

extragranular (not comparable) Of or pertaining to additional ingredients added to a material following granulation; outside of a granule.

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