What is intergenic suppression?

Intergenic suppression Intergenic (also known as extragenic) suppression relieves the effects of a mutation in one gene by a mutation somewhere else within the genome. The second mutation is not on the same gene as the original mutation.

What is Extragenic suppressor?

Extragenic suppression — overview Suppressing the effects of a mutant gene by changes elsewhere in the genome can occur in a number of ways. Extragenic suppression is usually revealed by crossing a revertant line with wildtype, and observing the re-appearance of the original mutant after Mendelian segregation.

What is an intergenic suppressor mutation?

Intergenic suppressor mutation is another type of a second mutation that occurs in a gene. It has the ability to restore the function of a protein produced by a second gene affected by a primary mutation. In other words, the second mutation does not occur in the gene with the primary mutation.

How do intergenic suppressors work?

An intergenic suppressor may occur in a gene that is in the same pathway as the original mutation, thereby restoring wild type activity levels within that pathway [12]. For instance, one gene may activate downstream targets of the pathway, while the other represses these targets.

What is intergenic interaction?

Intergenic interaction involves the interaction between two non-allelic genes, which is nothing but genes occupying different loci. Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits.

What is a second site suppressor?

Identifying rescue mutations, often referred to as second-site suppressor mutations, controls against scenarios in which the initial deleterious mutation inactivates the protein or disrupts alternative protein-protein interactions.

What does a suppressor mutation suppress what is the difference between an intergenic and a intergenic suppressor?

Suppressor Mutations. A suppressor mutation reverses or partially reverses the effects of a different mutation. An intragenic suppressor reverses the effect of a mutation at a different site in the same gene. An intergenic suppressor reverses the effect of a mutation at a different gene locus.

What is intergenic mutation?

Definition. A change in the nucleotide sequence of a region between gene loci. [ from NCI]

Which of the following is an example of intergenic?

Intergenic interaction is shown by polygenes. This type of interaction occurs when two or more alleles of different genes present on same or different chromosomes interact to produce a cumulative effect. Multiple alleles, co-dominance and incomplete dominance are the examples of intragenic interactions.

What is intergenic and intergenic interaction?

A It is an interaction between two non-allelic genes. C Pleiotropy is an example of intergenic interaction. Intergenic interaction involves the interaction between two non-allelic genes, which is nothing but genes occupying different loci.