What is IGF resistance?

Growth delay due to IGF-I resistance is characterised by variable intrauterine and postnatal growth retardation and elevated serum IGF-I levels.

Is IGF-1 deficiency genetic?

Insulin-like growth factor I deficiency is a genetic disease, which means that it is caused by one or more genes not working correctly.

Does IGF-1 cause insulin resistance?

IGF-I leads to an increase in peripheral glucose uptake and a decreased production of hepatic glucose causing better insulin sensitivity (2,23). Furthermore, low IGF-I serum concentrations were related to a higher anthropometric status, which in turn is related to insulin resistance.

Does resistance training increase IGF-1?

In the current study, IGF-1 levels were significantly increased in the exercise group after 12 months of resistance exercise training.

What causes HGH resistance?

The cause of GHD is often unknown, but genetic defects have been described in the receptor for GH releasing hormone from the brain and in the GH molecule, as well as in factors that lead to other hormone deficiencies along with GH.

How is Laron syndrome treated?

The only treatment option in Laron syndrome is recombinant human IGF1 administered subcutaneously at a dose of 80–120 μg/kg twice daily [10]. Recombinant IGF-1 was shown to accelerate the linear growth rate to 8–9 cm in the first year of treatment, compared with 10–12 cm/year during GH treatment of GH-deficiency.

What causes low IGF-1 levels in adults?

Causes and Risk Factors A lack of growth hormone is usually caused by damage to the pituitary gland or the hypothalamus, a part of the brain that controls the pituitary gland. The damage may be due to a tumor; to surgery or radiation used to treat the tumor; or to problems with the blood supply to the pituitary gland.

How does growth hormone cause insulin resistance?

GH therapy antagonizes insulin’s action on peripheral tissues, such as the skeletal muscle, liver, and adipose tissue, thereby increases glucose production from the skeletal muscle and liver and decreases glucose uptake from adipose tissue.

Does exercise decrease IGF-1?

LT exercise was found to significantly decrease the circulating levels of IGF-I, whereas IGFBP-1 was significantly increased.

How does exercise affect IGF?

The duration and intensity of physical activity have a significant impact on IGF-1 and IGFBP serum. The highest concentration of IGF-1 in serum was after eccentric training. “Overtraining” increases unfavorable and unbound IGF-1 levels and contributes to the increased incidence of hormone-cancer and osteoarthritis.

What causes IGF1 deficiency?

IGF1 deficiency (IGFD) can be caused by various conditions including growth hormone (GH) deficiency, nutritional deficiencies, and chronic inflammatory diseases (3, 4, 5). However, IGFD may occur as a primary disorder, with no identifiable cause.