What is HPC L?

(Low-substituted hydroxypropylcellulose) L-HPC is used as a binder and a disintegrant for solid dosage forms. It was brought onto the market in 1977, and then listed in the JP in 1986, in the NF in 1990 and in the EP in 2016. This product exhibits a wide range of compatibility with many active substances.

What is low substituted hydroxypropyl cellulose?

Low-substituted hydroxypropyl cellulose (L-HPC) is a low-substituted poly(hydroxypropyl) ether of cellulose. L-HPC is proposed for use as a food additive in food supplements in solid form (tablet), with a maximum use level of 20,000 mg/kg and a typical use level of 10,000 mg/kg.

Is crospovidone hygroscopic?

Crospovidone is a white, free-flowing, practically tasteless and odorless, hygroscopic powder. Crospovidone is a cross-linked, water-insoluble superdisintegrant.

What is HPMC polymer?

HPMC (Hydroxypropyl Methylcellulose) is the most commonly used cellulosic polymer available in various grades to develop such types of systems. Depending upon the molecular weight and viscosity chosen, it can be applied for emulsification, adhesion, bonding, thickening, suspension, film forming and gelation.

What is crospovidone used for?

It is medically used for the treatment of some intestinal disorders as solubilizing excipients to improve the bioavailability of drugs (such as steroids) and as germicides in wound treatment. It is also commonly used as a clarifier in alcoholic and nonalcoholic beverages.

What are the side effects of hydroxypropyl cellulose?

Side Effects

  • Blurred vision.
  • eye redness or discomfort or other irritation not present before use of this medicine.
  • increased sensitivity of eyes to light.
  • matting or stickiness of eyelashes.
  • swelling of eyelids.
  • watering of eyes.

How does hydroxypropyl cellulose work?

Hydroxypropyl cellulose (cellulose, 2-hydroxypropyl ether) is a derivative of cellulose with both water solubility and organic solubility. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states.

What is a disintegrant in tablets?

A disintegrant is an additive that promotes disintegration, which is the breakage of a tablet into small fragments when in contact with a liquid medium. In doing so, the surface area available for dissolution is increased and drug dissolution is accelerated.