What is HLA typing for platelets?

What is HLA typing for platelets?

What is an HLA-matched platelet? Human Leukocyte antigens (HLA) are proteins that are found on most cells in your body including platelets. An HLA-matched platelet is a blood component from a blood donor with an HLA type very similar to your own.

Who needs HLA platelets?

HLA-matched platelets are indicated for patients that have thrombocytopenia and have demonstrated CCI values consistent with immune refractory thrombocytopenia on at least two occasions.

What does human leukocyte antigen mean?

Listen to pronunciation. (HYOO-mun LOO-koh-site AN-tih-jen) A type of molecule found on the surface of most cells in the body. Human leukocyte antigens play an important part in the body’s immune response to foreign substances.

Can HLA b27 positive donate platelets?

You do not need to do anything if you test positive for HLA antibodies. Your HLA antibodies pose absolutely no risk to you. You will remain eligible to donate red blood cells. Unfortunately, you will no longer be eligible to donate plasma or plasma blood products, such as platelets collected by apheresis.

How is HLA match calculated?

The blood or cheek swab is tested in a lab to figure out your HLA type. Your HLA type will be compared to potential donors to see if there is a match. Your doctor will decide which donor has the best HLA match for you.

How many HLA types are there?

HLA are proteins that are located on the surface of the white blood cells and other tissues in the body. There are three general groups of HLA, they are HLA-A,HLA-B and HLA-DR. There are many different specific HLA proteins within each of these three groups.

Does everyone have HLA antigens?

The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. HLAs corresponding to MHC class I (A, B, and C), all of which are the HLA Class1 group, present peptides from inside the cell….Tables of variant alleles.

What does high HLA mean?

People with certain HLA antigens are more likely to develop certain autoimmune diseases, such as type I diabetes, ankylosing spondylitis, rheumatoid arthritis, celiac disease, SLE (systemic lupus erythematosus), myasthenia gravis, inclusion body myositis, Sjögren syndrome, and narcolepsy.