What is fish for MYC?

Rearrangements of MYC are typically tested for by fluorescence in situ hybridization (FISH). This method is currently considered the most accurate method for detection of oncogene amplification in human tumors (16) and is the gold standard for prediction of MYC rearrangement (17).

What is MYC translocation?

MYC is a potent oncogene initially identified as the target of the t(8;14)(q24;q32) chromosome translocation in Burkitt lymphoma. MYC gene alterations have been identified in other mature B-cell neoplasms that are usually associated with an aggressive clinical behavior.

What is MYC positive?

c-MYC expression is considered positive when >40% of the lymphoma cells are stained [49]. c-MYC expression detected by immunohistochemistry (IHC) does not equate to c-MYC rearrangement. However, there is a correlation between c-MYC expression by IHC and c-MYC gene abnormalities in aggressive B-cell lymphomas [53].

What is MYC Burkitt lymphoma?

INTRODUCTION. Burkitt lymphoma (BL) is a highly aggressive B cell neoplasm characterized by the translocation and deregulation of the MYC gene on chromosome 8. Three distinct clinical forms of BL are recognized: endemic, sporadic, and immunodeficiency-associated.

What is the function of Myc?

MYC gene encodes a multifunctional, nuclear phosphoprotein that controls a variety of cellular functions, including cell cycle, cell growth, apoptosis, cellular metabolism and biosynthesis, adhesion, and mitochondrial biogenesis.

What is Myc amplification?

MYC Amplification is an inclusion criterion in 2 clinical trials for non-small cell lung carcinoma, of which 0 are open and 2 are closed. Of the trials that contain MYC Amplification and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (0 open) and 1 is phase 1/phase 2 (0 open) [5].

What does the Myc gene do?

The c-Myc gene serves as a “master regulator” of cellular metabolism and proliferation. Since it is activated by a large number of oncogenic pathways and, in turn, stimulates many of the metabolic changes that result in malignant transformation, it is truly “both the chicken and the egg”.

What is the difference between myc and c-myc?

Myc and c-myc are the same thing, the normal cellular (hence the c) version of this protein, which can be oncogenic when mutated. The myc tag is a 10-residue sequence derived from c-myc, which is a much larger protein.