What is Fc virus?

Herpes simplex virus type 1 Fc receptor protects infected cells from antibody-dependent cellular cytotoxicity.

What is Fc antigen?

The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system.

What is Fc in protein?

Fc-fusion proteins are bioengineered polypeptides that join the crystallizable fragment (Fc) domain of an antibody with another biologically active protein domain or peptide to generate a molecule with unique structure–function properties and significant therapeutic potential.

How does Fc Engineering optimize the antibody?

Fc engineering is one attractive application to maximize the value or overcome the drawbacks of monoclonal antibodies for therapeutic use. With the Fc region, antibodies bind to several types of receptors, such as Fc gamma receptors, a complement receptor, and a neonatal Fc receptor.

How does Fc fusion work?

Fc-fusions are homodimers in which an Fc domain of an antibody is covalently linked to another protein. The fusion partner is usually directly attached to the flexible hinge (as shown), the length and sequence of which varies between different IgG subclasses.

What do we know about Fc receptor-mediated antiviral activities of antibodies?

Purpose of review: We summarize current information on Fc receptor-mediated antiviral activities of antibodies. These activities include Fcgamma receptor-mediated inhibition and neutralization of HIV on antigen-presenting cells, antibody-dependent cellular cytotoxicity, and antibody-dependent cell-mediated virus inhibition (ADCVI).

What are Fc receptors?

Its name is derived from its binding specificity for a part of an antibody known as the Fc (fragment crystallizable) region. Fc receptors bind to antibodies that are attached to infected cells or invading pathogens.

Why do Fc receptors have a low affinity for antigen?

The low individual affinity prevents Fc receptors from binding antibodies in the absence of antigen, and therefore reduces the chance of immune cell activation in the absence of infection. This also prevents agglutination (clotting) of phagocytes by antibody when there is no antigen.

What is the PMID for lymphocyte Fc receptors?

PMID 21900254. ^ Sandor M, Lynch RG (1993). “Lymphocyte Fc receptors: the special case of T cells”. Immunology Today. 14 (5): 227–231. doi: 10.1016/0167-5699 (93)90168-K. PMID 8517922.