What is EPA reference concentration?

Reference Concentration (RfC) It can be derived from a NOAEL, LOAEL, or benchmark concentration, with uncertainty factors generally applied to reflect limitations of the data used. Generally used in EPA’s noncancer health assessments.

What is reference concentration RfC?

Reference Concentration or “RfC” means an estimate of the continuous inhalation exposure to the human population, including sensitive subgroups and lifestages, that is likely to be without appreciable risk of adverse effect during a lifetime.

What is RfD and RfC?

The inhalation chronic RfD is derived from an inhalation chronic reference concentration (RfC). Inhalation subchronic RfD–the RfD used with inhalation doses under subchronic exposures to estimate the potential of a systemic toxic effect. The inhalation subchronic RfD is derived from an inhalation subchronic RfC.

How are reference doses calculated?

RfD = LOAEL/(UF x MF) = 25/8000 = 0.003 (mg/kg/day). Suppose the estimated exposure dose (EED) for humans exposed to the chemical under the proposed use pattern were 0.01 mg/kg/day (i.e., the EED is greater than the RfD).

What is EPA Iris?

The U.S. Environmental Protection Agency’s (EPA) Integrated Risk Information System (IRIS) Program develops human health assessments that provide health effects information on. environmental chemicals to which the public may be exposed, providing a critical part of the.

What is EPA RfC?

This ranking is based on EPA ‘s Reference Concentration (RfC). A RfC is an estimate of a continuous inhalation exposure concentration to people (including sensitive subgroups) that is likely to be without risk of deleterious effects during a lifetime.

What is RfC of a toxin?

The RfC is an estimate (with uncertainty spanning perhaps an order of magnitude) of a continuous inhalation exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime.

What is POD EPA?

In toxicology, point of departure (POD) is defined as the point on a toxicological dose-response curve established from experimental data or observational data generally corresponding to an estimated low effect level or no effect level.

How do you find the potency factor?

The CSF is also called a “potency factor” and is used to calculate the Incremental Lifetime Cancer Risk by multiplying the CSF by the chronic daily intake (CDI). The CDI is the dose over a lifetime and is expressed in mg/kg-day.