What is desmin a marker for?

Desmin is a specific marker for rhabdomyosarcomas of human and rat origin.

What is desmin sarcomere?

Desmin connects the Z-discs to one another, linking neighboring sarcomeres and forming myofibrils, the basic unit of muscle fibers. The connection of sarcomeres to each other to form myofibrils is essential for maintaining muscle fiber strength during repeated cycles of contraction and relaxation.

What is desmin in muscle?

Desmin is a subunit of intermediate filaments in cardiac muscle, skeletal muscle and smooth muscle tissue. In cardiac muscle, desmin is present in Z-discs and intercalated discs. Desmin has been shown to interact with desmoplakin and αB-crystallin.

What is vimentin and desmin?

Vimentin and desmin are intermediate filament proteins found in various mesenchymal and skeletal muscle cells, respectively. These proteins play an important role in the stabilization of the cytoplasmic architecture.

What is desmin test?

Identification of striated and smooth muscle cells and tumors derived from this cell type.

What is desmin immunohistochemistry?

Description: Desmin is a 53 kDa intermediate filament protein present in smooth muscle cells, striated muscle cells and myocardium. In skeletal and cardiac muscle cells, desmin filaments are localized in the Z-bands. Primary Antibody.

What are keratin and desmin?

The type III intermediate filament protein desmin is a homopolymeric protein normally expressed in muscle cells that, like epidermal keratinocytes, are subject to physical stress. While keratin filaments are type I/type II heteropolymers, desmin assembles as a type III homopolymer.

Where is desmin in the sarcomere?

Z disks
Associated with the end of the sarcomere, desmin intermediate filaments occupy a strategic position, linking individual myofibrils laterally at their Z disks and interconnecting sarcomeres to the sarcolemma membrane.

What does vimentin stain?

Vimentin stains virtually all spindle cell neoplasms—mesenchymal spindle cell neoplasms and sarcomatoid carcinomas included. However, vimentin stains a subset of carcinomas regularly and to a significant degree, and this may be useful in the context of a panel of antibodies to narrow a differential diagnosis.

What does EMA positive mean?

EMA is frequently positive in meningioma, which can be useful when distinguishing it from other intracranial neoplasms, e.g. Schwannomas. The absence of EMA can also be of value since negative EMA is characteristic of tumors such as adrenal carcinoma, seminomas, paraganglioma and hepatoma.

Is leiomyosarcoma desmin positive?

Leiomyosarcoma is generally a heterogeneous, well-circum-scribed tumor with an often cystic or necrotic central area. This tumor stains positive for desmin and smooth muscle actin.

What are the 5 functions of keratin?

Keratin protects epithelial cells, strengthens the skin, strengthens internal organs, controls the growth of epithelial cells, and maintains elasticity in the skin. It also holds epithelial cells together and helps them combat mechanical stress.