What is deletion of short arm of chromosome 4?

What is deletion of short arm of chromosome 4?

Wolf-Hirschhorn syndrome (WHS) is an extremely rare chromosomal disorder caused by a missing piece (partial deletion or monosomy) of the short arm of chromosome 4.

What is short arm syndrome?

Hypochrondroplasia is a genetic disorder characterized by small stature and disproportionately short arms, legs, hands, and feet (short-limbed dwarfism). Short stature often is not recognized until early to mid childhood or, in some cases, as late as adulthood.

What does the 4th chromosome do?

Chromosome 4 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 4 spans more than 186 million base pairs (the building material of DNA) and represents between 6 and 6.5 percent of the total DNA in cells….

What causes a baby to be born with short arms?

Achondroplasia is a type of rare genetic bone disorder. Achondroplasia is the most common type of these disorders. It causes the strong, flexible tissue called cartilage to not be made into bone as normal. This causes a series of signs, such as short arms and legs and a large head.

What is Jacobsen syndrome?

Jacobsen syndrome is a condition caused by a loss of genetic material from chromosome 11. Because this deletion occurs at the end (terminus) of the long (q) arm of chromosome 11, Jacobsen syndrome is also known as 11q terminal deletion disorder. The signs and symptoms of Jacobsen syndrome vary considerably.

What traits are on the 4th chromosome?

Gene mutations on chromosome 4 have been linked to genetic disorders and identified in several types of cancer. Examples of conditions associated with gene mutations on chromosome 4 include neurological and neurodegenerative disorders such as Parkinson’s disease, Huntington’s disease and narcolepsy.

Which disorder is due to 4th chromosomal abnormality?

Achondroplasia is a single gene disorder caused by certain mutations in the gene of chromosome 4.