What is DCA cancer treatment?

Dichloroacetate, or DCA, is a synthetic chemical used for cosmetic and clinical purposes. It’s commercially available as a cauterizing agent, meaning it burns the skin. This drug became popular in 2007 after a Canadian study suggested DCA might be able to reverse cancer growth.

What is the function of DCA?

Dichloroacetate (DCA) is a metabolic modulator that inhibits mitochondrial pyruvate dehydrogenase kinase and increases mitochondrial oxidative phosphorylation. DCA also depolarizes the mitochondria, causing release of H2O2 and cytochrome c.

What is sodium dichloroacetate?

Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and is an orally absorbable small molecular compound for MELAS syndrome, and children with congenital lactic acidosis and other diseases that are treated in the clinic (Michelakis et al., 2008, 2010).

Why is DCA toxic?

DCA appears to inhibit its own metabolism, which may influence the duration of its pharmacologic actions and lead to toxicity. DCA can cause a reversible peripheral neuropathy that may be related to thiamine deficiency and may be ameliorated or prevented with thiamine supplementation.

Is DCA available in Canada?

DCA is a prescription drug in Canada, USA and through most of Europe. It cannot legally be sold as a medication unless it is under a doctor’s prescription.

What is DCA made of?

DCA is a synthetic drug, but it is a very simple compound similar to a chemical combination of salt and vinegar. It works against cancer in a natural way (by triggering natural cell suicide).

How does Dichloroacetate treat lactic acidosis?

Dichloroacetate ameliorates lactic acidosis by increasing myocardial glucose oxidation and contractility and by inhibiting glycolysis, thereby decreasing lactate production, as well as by increasing lactate oxidation in peripheral tissues.

What are the side effects of DCA?

Sedation, confusion, hallucinations, memory problems, mood changes, hand tremors. These side effects are temporary and appear to be dose-dependent and age-dependent. This finding is consistent with existing human research on DCA that we have reviewed.

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How often do you do DCA?

Logically, then, DCA should not be used over periods of 2 or 3 years, not even 18 months. A DCA period between 6 and 12 months is probably best.

How do you calculate DCA?

How To Calculate DCA. The Formula: dividing the sum of total cost by the number of the total shares.