What is Cytolethal distending toxin B?

The Cytolethal Distending Toxin (CDT) is a bacterial virulence factor produced by several Gram-negative pathogenic bacteria. These bacteria, found in distinct niches, cause diverse infectious diseases and produce CDTs differing in sequence and structure.

What is CdtB?

CdtB is the active subunit and a homolog to mammalian DNase I, whereas CdtA and CdtC make up the binding subunit. Cytolethal distending toxins are produced by gram-negative pathogenic bacteria from the phylum Pseudomonadota.

Does Campylobacter release toxins?

Campylobacter jejuni is one of the major causes of infectious diarrhea worldwide. The distending cytolethal toxin (CDT) of Campylobacter spp. interferes with normal cell cycle progression. This toxic effect is considered a result of DNase activity that produces chromosomal DNA damage.

Does Cytolethal distending toxin cause diarrhea?

Cytolethal distending toxin-producing Escherichia coli strains causing severe diarrhoea in young Mexican children – PMC. The .

What does Cytolethal distending toxin do to humans?

Cytolethal distending toxin (CDT)-producing bacteria induce the DNA Damage Response (DDR). CdtB induces DNA double-strand breaks (DSBs). As a result of DSBs, DNA damage response (DDR) is activated.

Can Campylobacter cause arthritis?

Salmonella, Shigella, Yersinia, and Campylobacter may cause a gastrointestinal infection that can trigger reactive arthritis.

What autoimmune disease is associated with Campylobacter infections?

Campylobacter infection has been associated with a number of autoimmune diseases including arthritis (particularly affecting the knee joint), Reiter’s syndrome (a form of arthritis affecting the spine), conjunctivitis, and Guillain-Barré syndrome (a paralysing inflammatory disorder of the peripheral nerves).

How do you get Shiga?

Infection most typically occurs by eating contaminated food, particularly raw or undercooked meat. Infection can also occur after eating of any product contaminated with STEC, including lettuce, alfalfa sprouts, salami, and raw (unpasteurized) milk, juice, or cider. Infected people can spread E.

Can Campylobacter cause back pain?

Patients with Campylobacter‐triggered ReA The occurrence of ReA did not differ statistically significantly between the C. jejuni (7%) or C. coli (13%) groups. Nine of the ReA patients had inflammatory low back pain without peripheral arthritis.