What is congenital Nonspherocytic hemolytic anemia?

Congenital non-spherocytic hemolytic anemia (CNSHA) is an autosomal recessive condition that leads to a deficiency of vital enzymes required for glycolysis and red blood cell (RBC) nucleotide metabolism. It presents as a congenital hemolytic anemia and patients also show signs of jaundice.

What is Nonspherocytic anemia?

Summary. Hereditary nonspherocytic hemolytic anemia refers to a group of conditions for which the main feature is the premature destruction of red blood cells. Red blood cells move oxygen throughout the body. Premature destruction of red blood cells is called hemolytic anemia.

What is congenital haemolytic Anaemia?

Congenital hemolytic anemias (CHAs) are a heterogeneous group of rare hereditary conditions including defects of erythrocyte membrane proteins, red cell enzymes, and disorders due to defective erythropoiesis.

What are the types of congenital hemolytic anemia?

Types

  • Sickle cell anemia.
  • Congenital dyserythropoietic anemia.
  • Thalassemia.

What is the most common cause of hemolytic anemia?

Two common causes of this type of anemia are sickle cell anemia and thalassemia. These conditions produce red blood cells that don’t live as long as normal red blood cells.

What is the cause of hemolytic anemia?

Causes. The bone marrow is mostly responsible for making new red cells. Bone marrow is the soft tissue in the center of bones that helps form all blood cells. Hemolytic anemia occurs when the bone marrow isn’t making enough red cells to replace the ones that are being destroyed.

What are the 3 types of hemolysis?

Types

  • Alpha-hemolysis.
  • Beta-hemolysis.
  • Gamma-hemolysis.

What are the two types of hemolytic anemia?

The three main types of immune hemolytic anemia are autoimmune, alloimmune, and drug-induced.

  • Autoimmune hemolytic anemia (AIHA). In this condition, your immune system makes antibodies (proteins) that attack your red blood cells.
  • Alloimmune hemolytic anemia.
  • Drug-induced hemolytic anemia.

What is the treatment of hemolytic anemia?

Treatments for hemolytic anemia include blood transfusions, medicines, plasmapheresis (PLAZ-meh-feh-RE-sis), surgery, blood and marrow stem cell transplants, and lifestyle changes. People who have mild hemolytic anemia may not need treatment, as long as the condition doesn’t worsen.

What are the symptoms of hemolytic anemia?

What are the symptoms of hemolytic anemia?

  • Abnormal paleness or lack of color of the skin.
  • Yellowish skin, eyes, and mouth (jaundice)
  • Dark-colored urine.
  • Fever.
  • Weakness.
  • Dizziness.
  • Confusion.
  • Can’t handle physical activity.

What type of infections cause hemolytic anemia?

Some infections that are incriminated in hemolytic anemia and that can be transmission via blood transfusions include: hepatitis, CMV, EBV, HTLV-1, malaria, Rickettsia, Treponema, Brucella, Trypanosoma, Babesia, etc.

What is the difference between beta and alpha and gamma hemolysis?

The key difference between alpha beta and gamma hemolysis is that alpha hemolysis is the partial destruction of red blood cells in the blood and beta hemolysis is the complete destruction of red blood cells in the blood, while gamma hemolysis does not involve any breakdown of red blood cells.