What is claisen Schmidt condensation reaction?

The Claisen-Schmidt condensation reaction is an organic reaction in which a ketone or an aldehyde holding an α-hydrogen reacts with an aromatic carbonyl compound which does not have any α-hydrogens. This reaction is named after the chemists J.G. Schmidt and Rainer Ludwig Claisen.

Does Claisen-Schmidt have condensation?

The Claisen-Schmidt reaction (crossed-aldol reaction) is a condensation reaction of aldehydes and carbonyl compounds leading to β-hydroxycarbonyl compounds and it has played an important role in synthetic organic chemistry [1,2,3,4,5,6].

What is Claisen condensation mechanism?

The Claisen condensation is a carbon–carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base, resulting in a β-keto ester or a β-diketone. It is named after Rainer Ludwig Claisen, who first published his work on the reaction in 1887.

Which is an example of Claisen-Schmidt reaction?

Claisen Schmidt condensation: When a base-catalyzed cross aldol condensation between an aromatic aldehyde and an aliphatic aldehyde or a ketone is called Claisen Schmidt condensation or simply Claisen reaction. For example, Benzaldehyde reacts with Acetaldehyde to form 3-Phenylprop-2-en-1-al.

Why is Claisen condensation important?

Claisen Condensation of Thioesters: A Biochemical Process A variation on the Claisen condensation is an important biochemical reaction responsible for carbon–carbon bond formation in the biosynthesis of fatty acids. Also, a reverse Claisen condensation occurs in the catabolism of fatty acids.

Which compound is synthesized by Claisen-Schmidt reaction?

HAlMSN catalyzed the synthesis of (E)-chalcones through the Claisen–Schmidt reaction. Chalcone derivatives have been applied as biologically active compounds with anti-cancer, anti-inflammatory and diuretic pharmacological activities.

What is the starting material used in Claisen-Schmidt reaction?

The most widely used base catalyst is NaOH because of the greater yield [4]. Some base catalysts that have been used in the Claisen-Schmidt reaction are KOH (yield 88-94%) [5], Ba(OH)2 (yield 88-98%) [6], NaOH (yield 90-96%) [7].

What base is used in Claisen condensation?

The base of choice in Claisen condensation is the alkoxide ion corresponding to the alkoxy group in the ester.

Which of the following catalyst is used in the Claisen Schmidt condensation reaction?

Claisen-Schmidt Condensation reaction is the best method to synthesize chalcone derivatives by using strong base or acid such as sodium and potassium hydroxide, dry HCl, and aluminiumchloride18. Some of the organometallic catalysts such as Zn(bpy)(OAc)19,2 also were reported as catalysts for this reaction.