What is CDX2 in cancer?

CDX2 is a homeobox protein responsible for the maintenance of the intestinal phenotype [1, 2]. Over the last decade, CDX2 has been linked to colorectal cancer (CRC) progression, with reduced expression of the protein associated with more advanced tumor stage, vessel invasion, and metastasis [3–7].

Is CDX2 positive cancer?

These results suggest that positive CDX2 staining represents a highly sensitive and specific marker of metastatic colorectal carcinoma in both biopsy and resected specimens, and is superior to staining for the CK7-/20+ phenotype.

What is CDX2 staining?

Extensive positive Cdx2 staining predicts a metastasis from a gastrointestinal carcinoid of midgut or hindgut origin. Negative or focal Cdx2 staining predicts a source from the lung, stomach, biliary tract, or pancreas.

What does CDX2 negative mean?

CDX2-negative tumors are often associated with an increased likelihood of aggressive features, including advanced stage, poor differentiation, and vascular invasion and BRAF mutation. SEE ALSO: Know Your Biomarker for Metastatic Colorectal Cancer.

What does CDX2 stand for?

CDX2 is a homeobox gene that encodes a transcription protein factor that guides development of intestinal epithelial cells from the region of the duodenum to the rectum.357.

What is CDX2 and CK20?

CDX2 is a sensitive marker for rectal origin of adenocarcinoma. It can be helpful in cases with metastatic rectal carcinoma, especially those with CK7+/CK20+ or CK20-/CK7- immunophenotype. In this study, CDX2 expression was not influenced by the grade (differentiation) of rectal adenocarcinoma.

What does CK20 positive mean?

For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.

What is CK7 positive & CK20 positive mean?

What stains CK20?

They observed CK7 expression in the majority of lung, breast, endometrium, ovary, cervix, salivary gland, thyroid cancers, cholangiocarcinoma, and adenocarcinoma of the pancreas. In contrast, CK20 staining was seen in all colorectal adenocarcinomas and in the majority of gastric, pancreatic, and Merkel cell tumours.