What is C Myc and N-Myc?

The Myc proteins (c-Myc, L-Myc, S-Myc, and N-Myc) are a family of transcription factors that regulate growth and cell cycle entry by their ability to induce expression of genes required for these processes (44).

What does MYC gene stand for?

MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Immune response IL-2 activation and signaling pathway and Development IGF-1 receptor signaling.

How does C MYC cause cancer?

Myc transcription factor leads to upregulation of several genes which are involved in cell cycle progression, apoptosis, and cellular transformation, leading to increased cell number and thus, cancer. This gene is present on chromosome 8 and regulates almost 15% of all genes.

Why is MYC important?

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to new cancer therapeutic opportunities. MYC’s activation by bromodomain proteins could be inhibited by drug-like molecules, resulting in tumor inhibition in vivo.

What does c-myc positive mean?

c-MYC expression is considered positive when >40% of the lymphoma cells are stained [49]. c-MYC expression detected by immunohistochemistry (IHC) does not equate to c-MYC rearrangement. However, there is a correlation between c-MYC expression by IHC and c-MYC gene abnormalities in aggressive B-cell lymphomas [53].

How do you write c-myc?

The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

How do you say c-myc?

The viral gene is often symbolized v-myc and the cellular gene c-myc (pronounced “see-mick”).

What happens when you have a mutation in the Myc gene?

c-myc is often rearranged in tumors resulting in deregulated expression. In addition, mutations in the coding region of c-myc are frequently found in human lymphomas, a hot spot being the Thr58 phosphorylation site, a mutation shown to enhance the transforming capacity of c-Myc.

Is c-myc a tumor suppressor gene?

Abstract. The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation.

What is triple hit lymphoma?

Triple hit lymphoma is a rare and aggressive large B-cell lymphoma that carries translocations involving MYC, BCL2, and BCL6. Because of its low frequency, a relatively large case series of triple hit lymphomas to better characterize this tumor is not yet available in the literature.