What is bismuth Subcitrate potassium?
What is bismuth Subcitrate potassium?
Bismuth subcitrate potassium is a colloid used for the treatment of peptic ulcer and gastro-esophageal reflux disease (GERD). Pylera. Generic Name Bismuth subcitrate potassium DrugBank Accession Number DB09275 Background. A bismuth compound used for peptic ulcer and gastro-oesophageal reflux disease (GORD).
What is the reason bismuth is prescribed for patient with H. pylori?
Bismuth exerts direct bactericidal effect on Helicobacter pylori by different ways: forms complexes in the bacterial wall and periplasmic space, inhibits different enzymes, ATP synthesis, and adherence of the bacteria to the gastric mucosa.
Which drug is given with bismuth salt in Helicobacter pylori infection?
Abstract. Bismuth salts have been used in medicine for over three centuries, particularly in the treatment of dyspepsia. Commonly used agents include colloidal bismuth subcitrate (CBS), bismuth subsalicylate (BSS) and the newer ranitidine bismuth citrate (RBC).
What drugs are used to eradicate Helicobacter pylori?
The most important antibiotics in H. pylori treatment are clarithromycin, metronidazole, and amoxicillin. Figure 1 illustrates recently reported clarithromycin and metronidazole resistance rates worldwide. Resistance to these antibiotics is thought to be the main cause of eradication failure[27-29].
How does bismuth Subcitrate work?
Colloidal bismuth subcitrate (CBS) is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms. It has little acid-neutralizing effect and does not affect acid secretion. It is uncertain whether CBS affects pepsin secretion, but it does inhibit peptic activity.
Is bismuth Subcitrate the same as Pepto Bismol?
Bismuth subsalicylate, sold generically as pink bismuth and under the brand names Pepto-Bismol and BisBacter, is an antacid elixir medication used to treat temporary discomforts of the stomach and gastrointestinal tract, such as nausea, heartburn, indigestion, upset stomach, and diarrhea.
What is the most effective treatment for H. pylori?
To date, the bismuth-based triple therapies are the most effective and least costly treatments for the eradication of H pylori, because they have high cure rates even in those patients infected with metronidazole-resistant strains.
How long can you take bismuth for H. pylori?
| Regimen | Drugs (doses) | Duration (days) |
|---|---|---|
| Bismuth quadruple | PPI (standard dose¶) | 10 to 14◊ |
| Bismuth subcitrate (120 to 300 mg [not available in US] or 420 mg [available in North America and elsewhere as part of Pylera combination pill]) or Bismuth subsalicylate (300 or 524 mg) | ||
| Tetracycline (500 mg) | ||
| Metronidazole (250 to 500 mg) |
How do you take bismuth Subcitrate?
Administer three PYLERA capsules 4 times a day (after meals and at bedtime) for 10 days. One omeprazole 20 mg capsule should be taken twice a day with PYLERA after the morning and evening meal for 10 days (Table 1). Instruct patients to swallow the PYLERA capsules whole with a full glass of water (8 ounces).
Is bismuth Subcitrate the same as Pepto-Bismol?
What are the side effects of colloidal bismuth Subcitrate?
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- Belching.
- darkened urine.
- headache.
- muscle aches and pains.
- pains in the stomach, side, or abdomen, possibly radiating to the back.
- sore or dry throat.
- stomach discomfort, upset, or pain.
- unusual tiredness or weakness.
