What is bioresorbable vascular scaffolds?

Bioresorbable Vascular Scaffold is similar in appearance to a stent, but is a non-metallic, non-permanent, mesh implant which gets absorbed gradually, dissolves over time and allows the artery to function naturally again, similar to the way a cast supports a broken arm and is then removed.

What is a vascular scaffold?

Bioresorbable vascular scaffolds (BVS) are designed to provide mechanical support and drug delivery similar to the DES, followed by complete resorption over several years.

What are biomaterial scaffolds?

Scaffolds are three-dimensional (3D) porous, fibrous or permeable biomaterials intended to permit transport of body liquids and gases, promote cell interaction, viability and extracellular matrix (ECM) deposition with minimum inflammation and toxicity while bio-degrading at a certain controlled rate.

What are biocompatible scaffolds?

Scaffolds formed from natural polymers such as gelatin, chitosan, collagen, chondroitin sulphate and hyaluronic acid have received much attention due to their excellent physicochemical properties along with biodegradability and biocompatibility [12,13].

What is bioresorbable vascular scaffold made of?

The first generation of the bioabsorbable metal scaffold (AMS-1; Biotronik) was made from a WE43 alloy consisting of 93% magnesium and 7% rare-earth elements, with a strut thickness of 165 μm without drug coating59.

How do bioresorbable stents work?

While traditional metal stents are permanent implants and can restrict vessel motion, the Absorb bioresorbable stent is made of a dissolving polymer, similar to dissolving sutures, allowing the artery to pulse and flex naturally.

What are biological scaffolds made from?

Biological materials such as collagen, various proteoglycans, alginate-based substrates and chitosan have all been used in the production of scaffolds for tissue engineering. Unlike synthetic polymer-based scaffolds, natural polymers are biologically active and typically promote excellent cell adhesion and growth.

What are tissue scaffolds used for?

Cells, scaffolds and growth-stimulating signals are generally referred to as the tissue engineering triad, the key components of engineered tissues. Scaffolds, typically made of polymeric biomaterials, provide the structural support for cell attachment and subsequent tissue development.

What are bioresorbable stents made of?

Most bioresorbable stents are made of polylactic acid, a naturally dissolvable material that is used in medical implants such as dissolving sutures.