What is ATryn used for?

ATryn (Antithrombin [Recombinant]) is an important and welcome drug to prevent blood clots in patients who lack sufficient antithrombin (AT). About 1 in 5,000 Americans has AT deficiency, and these patients are at high risk for clotting during surgery and childbirth. Therefore, ATryn will be given in the hospital.

Is ATryn available in the US?

Along with the approval from the FDA’s pharmaceutical regulatory board, the Center for Veterinary Medicine of the FDA also approved the genetic makeup of the goats that are used to manufacture ATryn. rEVO has the sole rights to sell ATryn in the United States, and the drug is available in the U.S. market.

What is the function of recombinant human antithrombin produced in goats?

ATryn, a recombinant form of human antithrombin III (ATIII) produced in the milk of transgenic dairy goats, is an anticoagulant that is indicated for the treatment of patients with hereditary antithrombin deficiency to prevent the formation of blood clots during surgical procedures.

How is antithrombin produced?

Antithrombin (AT, Antithrombin III, ATIII) is a small glycoprotein produced by the liver that inactivates several enzymes of the coagulation system. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites.

Why was ATryn discontinued?

The withdrawal was at the request of the marketing authorisation holder, Laboratoire Francais du Fractionnement et des Biotechnologies, which notified the European Commission of its decision to permanently discontinue the marketing of the product for commercial reasons.

How is ATryn administered?

Dosage and Administration Administer loading dose as a 15-minute intravenous infusion immediately followed by continuous infusion of the maintenance dose. AT activity monitoring is required for proper treatment. Check AT activity once or twice per day and adjust dose accordingly.

Is ATryn discontinued?

How is atryn made?

Atryn comes from goats that were genetically engineered to have human antithrombin III in their milk. GTC Biotherapeutics, the company that makes Atryn, developed Atryn by injecting human antithrombin DNA into fertilized goat cells and implanting them in female goats.

What is a recombinant human antithrombin?

Antithrombin (Recombinant) is produced by recombinant DNA technology using genetically engineered goats into which the DNA coding sequence for human antithrombin has been introduced along with a mammary gland specific DNA sequence, which directs the expression of the antithrombin into the milk.

How is ATryn made?

What causes antithrombin deficiency?

Causes. Hereditary antithrombin deficiency is caused by mutations in the SERPINC1 gene. This gene provides instructions for producing a protein called antithrombin (previously known as antithrombin III). This protein is found in the bloodstream and is important for controlling blood clotting.

How are ATryn goats made?