What is ATRA used to treat?

ATRA is used to treat acute promyelocytic leukemia (APL, APML).

What is ATO ATRA?

ATRA and ATO therapy is a combination treatment of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) which is now recognised as the first-line treatment for acute promyelocytic leukaemia (APL). A first-line treatment is accepted as the best initial treatment for a given type and stage of a disease.

What are the side effects of ATRA?

ATRA can have side effects similar to those seen if you take too much vitamin A. Symptoms can include headache, fever, dry skin and mouth, skin rash, swollen feet, sores in the mouth or throat, itching, and irritated eyes. It can also cause blood lipid levels (like cholesterol and triglycerides) to go up.

How long is ATRA therapy?

The most common options for maintenance therapy are ATRA alone, or ATRA along with chemo (6-mercaptopurine (6-MP) and/or methotrexate). Maintenance therapy is typically given for about a year.

What is ATRA for leukemia?

All-Trans Retinoic Acid (ATRA) ATRA targets and eliminates the PML/RARα abnormality. This treatment causes a marked decrease in the concentration of leukemic blast cells in the marrow, and a remission frequently follows. Used alone, ATRA can induce a short-term remission in at least 80 percent of patients.

Can ATRA cause hair loss?

Trisenox has no known cross-resistance with ATRA or other anticancer agents. It does not cause hair loss and is not myelosuppressive in patients with APL.

How long can you live with acute promyelocytic leukemia?

APL is now considered a highly curable disease, with 2-year event-free survival rates of 75–84%. Early mortality is common in APL and is frequently related to hemorrhagic complications. Prior to ATRA therapy, early death (ED) related to hemorrhage occurred in up to 26% of cases.

Is ATRA and tretinoin the same?

Tretinoin is also called all trans retinoic acid (ATRA) and its brand name is Vesanoid. It belongs to a group of drugs called retinoids, these are similar to vitamin A.

How long does radiotherapy stay in your system?

The general effects of radiation therapy like fatigue, nausea, and headaches resolve fairly quickly after treatment. Your body just needs time to process the radiation but can recover within a few weeks.