What is antidepressant kindling?

Kindling is a term used to describe how some people slip down into the psychological rabbit hole of a mental health crisis in shorter periods of time and with less extreme triggers.

Which SSRI is least activating?

Citalopram and sertraline, which have relatively little effect on the P450 system and wash out of the body relatively quickly, are the least likely of the SSRIs to interact with a replacement drug.

Which antidepressants cause the most emotional blunting?

Antidepressants that commonly cause emotional blunting include:

  • selective serotonin reuptake inhibitors (SSRIs) escitalopram (Lexapro) paroxetine (Paxil) fluoxetine (Prozac) sertraline (Zoloft)
  • serotonin-norepinephrine reuptake inhibitors (SNRIs) duloxetine (Cymbalta) venlafaxine (Effexor XR) desvenlafaxine (Pristiq)

Does the kindling effect ever go away?

Avoiding the kindling effect means avoiding successive relapses. Kindling effects usually don’t start to happen unless someone has relapsed several times. The most effective way to prevent relapse is through ongoing, tailored treatment and support from trained doctors and therapists.

Can kindling be reversed?

There is no cure for the kindling effect, just as there is no cure for addiction or mental health disorders.

What is the kindling effect depression?

Overview of the Kindling Hypothesis The kindling hypothesis (Post, 1992) posits that initial episodes of a mood disorder are more likely to be influenced by psychosocial stressors compared to later episodes, upon which stressors are thought to have less of an effect.

What is the most stimulating SSRI?

Fluoxetine, considered one of the most stimulating SSRIs, is associated with increased awakenings and impaired sleep continuity.

Which SSRI has the least side effects?

Overall, citalopram appears to be the best-tolerated SSRI, followed by fluoxetine, sertraline, paroxetine, and fluvoxamine. The latter 2 drugs are associated with the most side effects and the highest discontinuation rates because of side effects in clinical trials.

Can Lexapro make you emotionless?

SSRI antidepressants are sometimes associated with something called emotional blunting. This can also include such symptoms as feeling indifferent or apathetic, being less able to cry and less able to experience the same degree of positive emotion as one normally would.

What drugs make you emotionally numb?

Prevalence of Emotional Blunting

  • Selective norepinephrine reuptake inhibitors (SNRIs) such as Cymbalta (duloxetine), Pristiq (desvenlafaxine), and Effexor XR (venlafaxine)
  • Selective serotonin reuptake inhibitors (SSRIs) like Lexapro (escitalopram), Prozac (fluoxetine), Zoloft (sertraline), and Paxil (paroxetine)

What is kindling phenomenon?

Kindling is a. phenomenon in which a weak electrical or chemical stimulus, which initially causes no overt. behavioral responses, results in the appearance of behavioral effects, such as seizures, when. it is administered repeatedly.

What is kindling with Benzos?

Kindling due to substance withdrawal refers to the neurological condition which results from repeated withdrawal episodes from sedative–hypnotic drugs such as alcohol and benzodiazepines.