What is AmniSure?

The Amnisure ROM test™ is a new method to diagnose rupture of the fetal membranes (ROM). The test detects placental alpha-microglobulin-1 (PAMG-1) in cervicovaginal fluid.

What does AmniSure negative mean?

One visible line means a negative result for amniotic fluid, two visible lines is a positive result, no visible lines is an invalid result). Two large studies have assessed the efficacy of AmniSure®.

What is a pamg-1 test?

Conclusion: Detection of the PAMG-1 in the vaginal fluid using AmniSure(®) test is an accurate method to diagnose rupture of the fetal membranes, with high sensitivity, specificity, negative and positive predictive values.

When can pamg-1 be detected?

Conclusions: PAMG-1 and IGFBP-1 can be detected in amniotic fluid between 15 and 20 completed WG, using respectively AmniSure and actim PROM.

How do you take Amnisure?

Procedure

  1. Collect sample of vaginal discharge with sterile collection swab (no speculum required).
  2. Rinse specimen swab in solvent vial. Discard swab.
  3. Insert amniotic fluid test strip into vial and remove if 2 lines are visible, or at 10 minutes sharp.
  4. Results are observed and recorded.

How sensitive is Amnisure?

Amnisure has been extensively studied, and is a great tool to detect rupture of membranes. Multiple studies have shown sensitivity of 99%, with high positive and negative predictive values.

How do you use Amnisure?

How reliable is Amnisure?

Is Amnisure affected by blood?

In fact, the specificity of AmniSure in the presence of blood (91.5%, this study) is greater than that of the IGFBP-1 test without vaginal bleeding (87.8%, this study) (Figure 4).

What color is amniotic fluid pH paper?

Because amniotic fluid is neutral (pH 7.0) or slightly alkaline (pH 7.25), it will change the yellow color of Nitrazine Paper. The pH values of blood, vaginal mucus, and certain secretions form vaginal infections are also Page 5 Procedures 5 Sterile Speculum Exam Policy and Procedure (con’t) alkaline.

How accurate is PartoSure?

Singleton Gestation (n=1,197) Negative Predictive Value (NPV) 473/482 98.1 (96.5, 99.1) For spontaneous preterm delivery ≤ 7 days in women with a singleton gestation, the PPV & NPV of the PartoSure test from the US and European Studies were 21.4% and 99.6%, and 31.0% and 98.1%, respectively.

What does Amnisure positive mean?

A positive Amnisure test in patients with preterm labor and intact membranes is a risk factor for adverse pregnancy outcome, particularly in patients with a negative fetal fibronectin test.

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