What is Alpha Ketoglutaric acid used for?
What is Alpha Ketoglutaric acid used for?
People use it to make medicine. Alpha-ketoglutarate is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.
Is Alpha-ketoglutarate toxic?
Abstract. Oral treatment of alpha-ketoglutarate (A-KG) is known to antagonise experimental cyanide poisoning in rodents. Maximum protective efficacy of A-KG has been observed at a dose of 2.0 g kg-1 body weight but no acute toxicity has been observed at this dose level.
Why is alpha-ketoglutarate important?
Alpha-Ketoglutarate (AKG) is a biological substance that plays important roles in cell metabolism and physiology. AKG is synthesized from glucose or oxaloacetate plus pyruvate. As an intermediate of the tricarboxylic acid cycle, AKG is essential for the oxidation of fatty acids, amino acids, and glucose.
What does high alpha-ketoglutarate mean?
– Higher levels are seen in mitochondrial oxidative phosphorylation disorders and mitochondrial dysfunction. – Genetic abnormalities with the enzyme itself can also limit conversion of alpha-ketoglutarate, causing elevations.
What is AKG supplement good for?
AKG is part of the metabolic cycle that our cells use to make energy from food. In addition to its use by bodybuilders, doctors sometimes treat osteoporosis and kidney disease with the supplement.
What are the benefits of AKG?
AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications.
Is alpha-ketoglutarate same as alpha Ketoglutaric acid?
Alpha-ketoglutaric acid is one of two ketone derivatives of glutaric acid. (The term “ketoglutaric acid,” when not further qualified, almost always refers to the alpha variant….
| Alpha-ketoglutaric acid | |
|---|---|
| Melting point | 113.5 |
Is there another name for alpha-ketoglutarate?
Its carboxylate, α-ketoglutarate also called 2-oxoglutarate, is an important biological compound. It is the keto acid produced by deamination of glutamate, and is an intermediate in the Krebs cycle.
Why is it called alpha-ketoglutarate?
α-Ketoglutaric acid (2-oxoglutaric acid) is one of two ketone derivatives of glutaric acid. The term “ketoglutaric acid,” when not further qualified, almost always refers to the alpha variant.
What is alpha-ketoglutarate converted to?
Alpha-ketoglutarate dehydrogenase (α-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. It catalyses the conversion of α-ketoglutarate to succinyl-CoA and produces NADH directly providing electrons for the respiratory chain.
