What is a toxic metabolic disease?

Acute toxic-metabolic encephalopathy (TME), which encompasses delirium and the acute confusional state, is an acute condition of global cerebral dysfunction in the absence of primary structural brain disease [1].

What is a metabolic disease definition?

metabolic disease, any of the diseases or disorders that disrupt normal metabolism, the process of converting food to energy on a cellular level. Thousands of enzymes participating in numerous interdependent metabolic pathways carry out this process.

What is an example of a metabolic disease?

Metabolic syndrome is a cluster of conditions that occur together, increasing your risk of heart disease, stroke and type 2 diabetes. These conditions include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.

What is the difference between toxic and metabolic encephalopathy?

Toxic encephalopathy describes acute mental status alteration due to medications, illicit drugs, or toxic chemicals. Metabolic encephalopathy is caused by any of a large number of metabolic disturbances. Toxic-metabolic encephalopathy describes a combination of toxic and metabolic factors.

What can cause toxic-metabolic encephalopathy?

TME is debilitating for some, especially as we age, and may cause changes in physical and cognitive functioning. The causes of TME are numerous and varied. Some causes are infections, dehydration, malnutrition, alcohol toxicity, liver/kidney disease, metabolic imbalances, or reduced oxygen to the brain.

What is the most common metabolic disease?

Diabetes is the most common metabolic disease. There are two types of diabetes: Type 1, the cause of which is unknown, although there can be a genetic factor.

What are the major metabolic diseases?

Diabetes is the most common metabolic disease. There are two types of diabetes: Type 1, the cause of which is unknown, although there can be a genetic factor. Type 2, which can be acquired, or potentially caused by genetic factors as well….Hereditary hemochromatosis

  • liver cirrhosis.
  • liver cancer.
  • diabetes.
  • heart disease.

Can you recover from toxic metabolic encephalopathy?

Metabolic encephalopathies usually develop acutely or subacutely and are reversible if the systemic disorder is treated. If left untreated, however, metabolic encephalopathies may result in secondary structural damage to the brain.

What medications can cause toxic encephalopathy?

Many drugs may cause toxic encephalopathy….Toxic encephalopathy.

Type of therapeutic agent Drugs
Antineoplastic agents Methotrexate (± seizures, leukotoxic damage)
Ifosfamide
Paclitaxel (± seizures)
Cisplatin (± seizures, leukotoxic damage)